Results 71 to 80 of about 20,352 (205)
Advanced Science, EarlyView.Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu +6 more
wiley +1 more source
Translational Oncology, 2023 Purpose: Our study explored the effect of long noncoding RNA BBOX1-AS1 on colorectal cancer (CRC) radiosensitivity in vivo and in vitro. Methods: Differentially expressed lncRNAs in CRC were screened using a bioinformatics database and an online ...
Qi Wang +8 more
doaj
Pharmaceuticals, 2022 The full understanding of the complex nature of cancer still faces many challenges, as cancers arise not as a result of a single target disruption but rather involving successive genetic and epigenetic alterations leading to multiple altered metabolic ...
Ioana-Ecaterina Pralea +9 more
doaj +1 more source
Advanced Science, EarlyView.The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang +15 more
wiley +1 more source
Frontiers in Physiology, 2019 Intermittent fasting is used to reduce body mass in obese adult humans and animals. However, information on the impact of one type of intermittent fasting (IF) called every-other-day feeding (EODF) on young animals is scarce.
Oksana M. Sorochynska +8 more
doaj +1 more source
Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant
Biotechnology and Bioengineering, EarlyView.ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida +7 more
wiley +1 more source
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]
, 2016 A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon +15 more
core +2 more sources
Ubiquitination in cancer: mechanisms and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu +7 more
wiley +1 more source
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis [PDF]
, 2016 Metabolic changes are associated with cancer, but whether they are just bystander effects of deregulated oncogenic signaling pathways or characterize early phases of tumorigenesis remains unclear.
Angioni, Maria Maddalena +16 more
core +3 more sources
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
Cell Biology International, EarlyView.ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio +6 more
wiley +1 more source