Results 71 to 80 of about 21,592 (215)

Sodium bicarbonate treatment during transient or sustained lactic acidemia in normoxic and normotensive rats. [PDF]

PLoS ONE, 2012
INTRODUCTION: Lactic acidosis is a frequent cause of poor outcome in the intensive care settings. We set up an experimental model of lactic acid infusion in normoxic and normotensive rats to investigate the systemic effects of lactic acidemia per se ...
Franco Valenza, Marta Pizzocri, Valentina Salice, Giorgio Chevallard, Tommaso Fossali, Silvia Coppola, Sara Froio, Federico Polli, Stefano Gatti, Francesco Fortunato, Giacomo P Comi, Luciano Gattinoni   +11 more
doaj   +1 more source

Coxsackievirus B3 infection induces glycolysis to facilitate viral replication

Frontiers in Microbiology, 2022
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strategy against CVB3 is available. Viruses lack an inherent metabolic system and thus depend on host cellular metabolism for their benefit.
Yujie Qian, Yeyi Yang, Wenxiang Qing, Chunyun Li, Min Kong, Zhijuan Kang, Yuanbojiao Zuo, Jiping Wu, Meng Yu, Zuocheng Yang   +9 more
doaj   +1 more source

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras [PDF]

, 2017
Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism linking fermentation to activation of Ras, a major regulator of cell proliferation in yeast and ...
Bonini, B. M., Fischer, B., Peeters, K., Quezada, H., Tompa, Péter, Van Leemputte, F.   +5 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis [PDF]

, 2016
Metabolic changes are associated with cancer, but whether they are just bystander effects of deregulated oncogenic signaling pathways or characterize early phases of tumorigenesis remains unclear.
Angioni, Maria Maddalena, Chiarugi, Paola, Columbano, Amedeo, Fornari, Francesca, Giordano, Silvia, Gramantieri, Laura, Guzzo, Giulia, Kowalik, Marta Anna, Ledda Columbano, Giovanna Maria, Masgras, Ionica, Menegon, Silvia, Morandi, Andrea, Perra, Andrea, Quagliata, Luca, Rasola, Andrea, Terracciano, Luigi, Trevisan, Elena   +16 more
core   +3 more sources

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. [PDF]

, 2017
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra.
Anandhan, Annadurai, Cerny, Ronald, Dodds, Eric, Franco, Rodrigo, Huang, Yuting, Lei, Shulei, Marshall, Darrell, Panagiotidis, Mihalis, Pappa, Aglaia, Powers, Robert, Worley, Bradley   +10 more
core   +2 more sources

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Role of Th1/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2, phosphofructokinase-1, and pyruvate kinase M2 in oral lichen planus

Romanian Journal of Laboratory Medicine
We aimed to explore the role of T helper cell 1 (Th1)/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2 (HK2), phosphofructokinase-1 (PEK1) and pyruvate kinase M2 (PKM2) in oral lichen planus (OLP).
Yao Min, Li Lijuan, Xiao Lingling, Zhuang Yunxia, Sun Guangrong   +4 more
doaj   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source