Results 11 to 20 of about 28,503 (264)

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Nature Communications, 2021
Glycolytic enzymes are challenging drug targets due to their highly conserved active sites and phosphorylated substrates. Here, the authors identify fast acting allosteric inhibitors of Trypanosoma brucei phosphofructokinase that block trypanosome ...
Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw   +21 more
doaj   +2 more sources

Expression of phosphofructokinase in Neisseria meningitidis [PDF]

Microbiology, 2010
Neisseria meningitidisserogroup B is a pathogen that can infect diverse sites within the human host. According to theN. meningitidisgenomic information and experimental observations, glucose can be completely catabolized through the Entner–Doudoroff pathway and the pentose phosphate pathway. The Embden–Meyerhof–Parnas pathway is not functional, because
Baart, G.J.E., Langenhof, M., van de Waterbeemd, B., Hamstra, H.J., Zomer, B., van der Pol, L.A., Beuvery, E.C., Tramper, J., Martens, D.E.   +8 more
openaire   +6 more sources

Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood ...
Lee B. Bockus, Satoshi Matsuzaki, Shraddha S. Vadvalkar, Zachary T. Young, Jennifer R. Giorgione, Maria F. Newhardt, Michael Kinter, Kenneth M. Humphries   +7 more
doaj   +2 more sources

First description of phosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene

Frontiers in Physiology, 2013
Phosphofructokinase deficiency is a very rare autosomal recessive disorder, which belongs to group of rare inborn errors of metabolism called glycogen storage disease. Here we report on a new mutation in the phosphofructokinase (PFK) gene PFKM identified
Pavla Koralkova, Richard W Eastes
exaly   +3 more sources

Increasing the Thermodynamic Driving Force of the Phosphofructokinase Reaction in Clostridium thermocellum

Applied and Environmental Microbiology, 2022
The ability to control the distribution of thermodynamic driving force throughout a metabolic pathway is likely to be an important tool for metabolic engineering.
Shuen Hon, Tyler B. Jacobson, David M. Stevenson, Marybeth I. Maloney, Richard J. Giannone, R. Hettich, D. Amador-Noguez, D. Olson, L. Lynd   +8 more
semanticscholar   +1 more source

In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis

Microbiology Spectrum, 2022
Streptococcus thermophilus is widely used in the dairy industry for the manufacturing of fermented milk and cheeses and probiotic formulations. S. thermophilus evolved from closely phylogenetically related pathogenic streptococci through loss-of-function
Stefania Arioli, Giulia Della Scala, Anđela Martinović, Leonardo Scaglioni, Stefania Mazzini, Federica Volonté, Martin Bastian Pedersen, Diego Mora   +7 more
doaj   +1 more source

The activities of fructose 1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle [PDF]

Biochemical Journal, 1967
1. The activities of fructose 1,6-diphosphatase were measured in extracts of muscles of various physiological function, and compared with the activities of other enzymes including phosphofructokinase, phosphoenolpyruvate carboxykinase and the lactate ...
LH Opie, E. A. Newsholme
openalex   +2 more sources

White Spot Syndrome Virus Triggers a Glycolytic Pathway in Shrimp Immune Cells (Hemocytes) to Benefit Its Replication

Frontiers in Immunology, 2022
White spot syndrome virus (WSSV) is the causative agent of a shrimp disease that inflicts in huge economic losses in shrimp-farming industry. WSSV triggers aerobic glycolysis in shrimp immune cells (hemocytes), but how this virus regulates glycolytic ...
Yen Siong Ng, Der-Yen Lee, Chun-Hung Liu, Cheng-Yi Tung, Shu-Ting He, Han-Ching Wang, Han-Ching Wang   +6 more
doaj   +1 more source

Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase

Journal of Biological Chemistry, 1966
Bakula Trivedi, William H. Danforth
openalex   +2 more sources

Roles of GFAT and PFK genes in energy metabolism of brown planthopper, Nilaparvata lugens

Frontiers in Physiology, 2023
Glutamine:fructose-6-phosphate aminotransferases (GFATs) and phosphofructokinase (PFKs) are the principal rate-limiting enzymes involved in hexosamine biosynthesis pathway (HBP) and glycolysis pathway, respectively.
Hui-Ru Si, Hui-Ru Si, Si-Si Sun, Yong-Kang Liu, Ling-Yu Qiu, Ling-Yu Qiu, Bin Tang, Fang Liu, Qiang Fu, Cai-Di Xu, Pin-Jun Wan   +10 more
doaj   +1 more source