Results 51 to 60 of about 28,503 (264)

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

eLife, 2019
Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive.
Kenneth Kin Lam Wong, Jenny Zhe Liao, Esther M Verheyen   +2 more
doaj   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Significance of phosphorylation of phosphofructokinase.

Journal of Biological Chemistry, 1983
In order to understand the effect of phosphorylation on phosphofructokinase, the allosteric kinetic behavior, ligand binding at various pHs, and pH-dependent cold inactivation of phosphofructokinase phosphorylated to different extents were studied. A subtilisin-digested phosphofructokinase from which a COOH-terminal peptide containing a phosphorylation
Ryuzo Sakakibara, Kosaku Uyeda, S Kitajima   +2 more
openaire   +3 more sources

Purification of human erythrocyte phosphofructokinase [PDF]

FEBS Letters, 1972
Phosphofmctokinase* has been isolated from several mammalian tissues in highly purified or even crystallized forms [l-6] . Human PFK received greater attention when a new human disease was detected, which could be characterized by a deficiency of muscle PFK and a decrease of the enzyme in red blood cells to about 50% of normal.
Eberhard Hofmann, K.-W. Wenzel, Gerolf Zimmermann, J. Gauer   +3 more
openaire   +3 more sources

Genome-wide survey of the phosphofructokinase family in cassava and functional characterization in response to oxygen-deficient stress

BMC Plant Biology, 2021
Background Glycolytic pathway is common in all plant organs, especially in oxygen-deficient tissues. Phosphofructokinase (PFK) is a rate-limiting enzyme in the glycolytic pathway and catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6 ...
Haiyan Wang, Pingjuan Zhao, Xu Shen, Zhiqiang Xia, Xincheng Zhou, Xin Chen, Cheng Lu, WenquanWang   +7 more
doaj   +1 more source

Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida, Ken Miyazawa, Hikaru Ichikawa, Kiyoaki Muto, Akira Yoshimi, Toshitaka Kumagai, Yoshikazu Kato, Keietsu Abe   +7 more
wiley   +1 more source

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

ACS Medicinal Chemistry Letters, 2014
Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and ...
K. Brimacombe, M. Walsh, Li Liu, Montserrat G. Vásquez-Valdivieso, H. P. Morgan, I. McNae, L. Fothergill-Gilmore, P. Michels, D. Auld, A. Simeonov, M. Walkinshaw, M. Shen, M. Boxer   +12 more
semanticscholar   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

Cell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio, Ariely Barbosa Leite, Ana Caroline de Castro Nascimento Sousa, Suellen Rodrigues Maran, Antoniel Augusto Severo Gomes, Elton J. R. Vasconcelos, Nilmar Silvio Moretti   +6 more
wiley   +1 more source