Results 71 to 80 of about 28,503 (264)

An INS‐1 832/13 𝛽‐Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose‐Stimulated Insulin Secretion

PROTEOMICS, EarlyView.
ABSTRACT Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucose‐stimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INS‐1 832/13 beta cells that were short‐term stimulated with 11 different glucose concentrations from 0 to 20 mM, quantifying the response of 3703 proteins ...
Nina Stremmel, Oliver Lemke, Kathrin Textoris‐Taube, Daniela Ludwig, Michael Mülleder, Julia Muenzner, Markus Ralser   +6 more
wiley   +1 more source

Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage

VIEW, EarlyView.
A high‐glucose environment induced an imbalance in mitochondrial homeostasis, which resulted in the inhibition of bone tissue regeneration. In this study, we first introduce the exogenous noninvasive direct current electric field (DCEF) strategy for regulating mitochondrial homeostasis and explore its effect on bone regeneration in high‐glucose ...
Dongzong Huang, Rongchen Xu, Changzhen Xu, Peng Xue, Lin Liu, Yiping Fan, Miaoshen Guan, Menglin Luo, Shaoyuan Cui, Xiaoyu Wang, Jin Liu, Chunyu Zhang, Bo Fu, Hua Jiang, Hongbo Li   +14 more
wiley   +1 more source

The structure of “activation factor” for phosphofructokinase. [PDF]

Journal of Biological Chemistry, 1981
The "activation factor" for phosphofructokinase was shown by chemical analysis, by synthesis, and by 13C NMR spectroscopy to be beta-D-fructose-2,6-P2. This compound was prepared from D-fructose-1,2-cyclic 6-P2 by alkaline hydrolysis. D-Fructose-1,2-cyclic 6-P2 is ineffective in activating phosphofructokinase while synthetic D-fructose-2,6-P2 has the ...
Eisuke Furuya, A. D. Sherry, Kosaku Uyeda   +2 more
openaire   +2 more sources

Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development

Frontiers in Oncology, 2020
Metabolism plays a critical role in direct regulation of a variety of cellular activities via metabolic enzymes and metabolites. Here, we demonstrate that phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in ...
Jong-Ho Lee, Fei Shao, Jinjie Ling, Sean Lu, Rui Liu, Linyong Du, Jin Woong Chung, Sang Seok Koh, Sun-Hee Leem, Jichun Shao, Dongming Xing, Dongming Xing, Zhiqiang An, Zhimin Lu   +13 more
doaj   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Insulin resistance and exercise‐induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics

Journal of Diabetes Investigation, EarlyView.
Insulin resistance in muscle mainly disrupts non‐canonical insulin signaling pathways. Exercise‐induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
Shun Masuda, Takashi Matsuzaka
wiley   +1 more source

Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA

Journal of Biological Chemistry, 2011
The enzyme phosphofructokinase-1 (PFK-1) catalyzes the first committed step of glycolysis and is regulated by a complex array of allosteric effectors that integrate glycolytic flux with cellular bioenergetics. Here, we demonstrate the direct, potent, and
C. M. Jenkins, Jingyue Yang, H. Sims, R. Gross   +3 more
semanticscholar   +1 more source

Assessing Cofactor Usage in Pseudoclostridium thermosuccinogenes via Heterologous Expression of Central Metabolic Enzymes

Frontiers in Microbiology, 2019
Pseudoclostridium thermosuccinogenes and Hungateiclostridium thermocellum are being studied for their potential to contribute to a more sustainable bio-based economy.
Jeroen Girwar Koendjbiharie, Kimberly Wevers, Richard van Kranenburg, Richard van Kranenburg   +3 more
doaj   +1 more source

Cell death‐inducing DNA fragmentation factor alpha (DFFA)‐like effectors (CIDEs) improve lipid droplet (LD) formation and oil accumulation in plant tissues

Plant Biotechnology Journal, EarlyView.
Summary The cell death‐inducing DNA fragmentation factor alpha (DFFA)‐like effectors (CIDEs), including CIDEA, CIDEB and CIDEC, regulate the number and size of lipid droplets (LDs) in vertebrates. However, no homologue of CIDE has been reported in plants.
Yao Xiong, Caiyi Sun, Yuyan Xiang, Yuqing Li, Liang Guo, Shaoping Lu   +5 more
wiley   +1 more source

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao   +9 more
wiley   +1 more source