Results 81 to 90 of about 40,035 (261)

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Nature Communications, 2019
Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting ...
Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil, Mei Kong   +11 more
doaj   +1 more source

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

Plant Biotechnology Journal, EarlyView.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang, Jiying Li, Zhang Wang, Miao Yu, Chang Liu, Dongye Liu, Ruohan Wang   +6 more
wiley   +1 more source

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Nature Communications, 2017
Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced
Jong-Ho Lee, Rui Liu, Jing Li, Chuanbao Zhang, Yugang Wang, Qingsong Cai, Xu Qian, Yan Xia, Yanhua Zheng, Yuji Piao, Qianming Chen, John F. de Groot, Tao Jiang, Zhimin Lu   +13 more
doaj   +1 more source

In vitro quality assessment of red blood cells and plasma units in DEHT/SAGM bags and DEHT/PAGGSM bags during storage

Vox Sanguinis, EarlyView.
Abstract Background and Objectives DEHT is considered a safer alternative to DEHP, a commonly used plasticizer with potential toxicological risks. We aimed to compare the storage efficacy of red blood cells (RBCs) in DEHT bags containing two different additive solutions: SAGM and PAGGSM.
Anaïs Lotens, Tome Najdovski, Nicolas de Valensart, Nicolas Cellier, Chryslain Sumian, Quentin Brebant, Christian Naegelen, Constant Cretenet, Nadine Marpaux   +8 more
wiley   +1 more source

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Cancer & Metabolism, 2020
Background High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC ...
D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce   +4 more
doaj   +1 more source

Transcriptome pathways unique to dehydration tolerant relatives of modern wheat [PDF]

, 2009
Among abiotic stressors, drought is a major factor responsible for dramatic yield loss in agriculture. In order to reveal differences in global expression profiles of drought tolerant and sensitive wild emmer wheat genotypes, a previously deployed shock ...
AN Olsen, B Barnabas, B Vinocur, C Guy, D Bartels, DB Lobell, E Ormeno, EA Bray, G Toledo-Ortiz, GP Xue, GR Cramer, Hans J. Bohnert, HG Jones, Hikmet Budak, HJ Bohnert, IK Vasil, J Dubcovsky, J Zhou, JL Araus, Jyothi Thimmapuram, K Deuschle, K Higuchi, K Higuchi, K Poustini, K Shinozaki, L Cseke, L Rodriguez-Uribe, L Xiong, M Mohammadi, M Seki, MB Eisen, N Kaur, NC Collins, Neslihan Z. Ergen, O Cebeci, P Langridge, P Rampino, PBK Kishor, PY Muller, R Kaldenhoff, R Munns, S Chao, S Mahajan, S Ramanjulu, T Eulgem, The Gene Ontology Consortium, V Talame, W Li, W Wang, YG Shen, YH Lee, ZN Ergen, ZN Ergen, ZN Ozturk   +53 more
core   +1 more source

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

Nature Communications, 2018
TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in
Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang, Peng Jiang   +15 more
doaj   +1 more source

Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer

, 2021
Takahiro Inaishi, Masahiro Shibata, Takahiro Ichikawa, Mitsuro Kanda, Masamichi Hayashi, Ikumi Soeda, Dai Takeuchi, Yuko Takano, Nobuyuki Tsunoda, Yasuhiro Kodera, Toyone Kikumori   +10 more
openalex   +2 more sources

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source