Results 81 to 90 of about 28,503 (264)

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Cell Reports, 2023
Summary: The ATP-sensitive K+ (KATP) channel is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of KATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice,
Thuong Ho, Evgeniy Potapenko, Dawn B. Davis, Matthew J. Merrins   +3 more
doaj  

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Cancer & Metabolism, 2020
Background High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC ...
D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce   +4 more
doaj   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Speed Endurance Training to Improve Performance

Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 7, July 2025.
ABSTRACT In many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and ...
Jens Bangsbo, Julie Kissow, Morten Hostrup   +2 more
wiley   +1 more source

Antibiotic Overproduction in Streptomyces coelicolor A3(2) Mediated by Phosphofructokinase Deletion*

Journal of Biological Chemistry, 2008
Streptomycetes are exploited for production of a wide range of secondary metabolites, and there is much interest in enhancing the level of production of these metabolites.
I. Borodina, Jeroen Siebring, Jie Zhang, Colin P. Smith, G. van Keulen, L. Dijkhuizen, J. Nielsen   +6 more
semanticscholar   +1 more source

Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1

AJP - Renal Physiology, 2008
The vacuolar-type ATPase (H+ATPase) is a ubiquitously expressed multisubunit pump whose regulation is poorly understood. Its membrane-integral a-subunit is involved in proton translocation and in humans has four forms, a1–a4.
Ya-Chi Su, K. Blake-Palmer, Sara L. Sorrell, B. Javid, K. Bowers, Aiwu Zhou, Simon H. Chang, S. Qamar, F. Karet   +8 more
semanticscholar   +1 more source

Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways

Microbial Cell Factories, 2019
Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow, especially at low salinity ...
José M. Pastor, Nuno Borges, Juan P. Pagán, Sara Castaño-Cerezo, Laszlo N. Csonka, Bradley W. Goodner, Kathryn A. Reynolds, Luís G. Gonçalves, Montserrat Argandoña, Joaquín J. Nieto, Carmen Vargas, Vicente Bernal, Manuel Cánovas   +12 more
doaj   +1 more source

Distribution of nesfatin-1 expression in Bactrian camels and its impact on adipocyte glucose metabolism [PDF]

Pesquisa Veterinária Brasileira
: The study aimed to investigate the distribution and expression of nesfatin-1 in Bactrian camels and its impact on adipocyte glucose metabolism. Polyclonal antibodies against a single antigenic epitope of NUCB2/nesfatin-1 protein were prepared. Nesfatin-
Siriguleng Yu, Bijun Chen, Haoyu Bai, Ziyi Li, Yaru Niu, Xingchuan He, Wen Yu, Shumin Du, Junjian Jin, Hongqiang Yao   +9 more
doaj   +1 more source

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

Biochemical Journal, 1980
The low-molecular-weight stimulator of phosphofructokinase [Van Schaftingen, Hue & Hers (1980) Biochem. J. 192, 887-895] has been purified from rat liver. It was completely destroyed upon incubation with 0.01 M-HCl for 10 min at 20 degrees C and fructose
E. Schaftingen, Louis Hue, H. Hers
semanticscholar   +1 more source