Results 101 to 110 of about 34,103 (213)

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

Biomolecules
The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression
Xiaomin Wu, Boshi Wang, Yingjian Hou, Yipeng Fang, Yuan Jiang, Yuelei Song, Youyi Liu, Cheng Jin   +7 more
doaj   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Prognostic Roles of Phosphofructokinase Platelet in Clear Cell Renal Cell Carcinoma and Correlation with Immune Infiltration

International Journal of General Medicine, 2021
Bin Liu,1 Faping Li,1 Mingdi Liu,2 Zhixiang Xu,2 Baoshan Gao,1 Yishu Wang,2 Honglan Zhou1 1Department of Urology, the First Hospital of Jilin University, Changchun, 130021, Jilin, People’s Republic of China; 2Key Laboratory of Pathobiology, Ministry of ...
Liu B, Li F, Liu M, Xu Z, Gao B, Wang Y, Zhou H   +6 more
doaj  

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

Plant Biotechnology Journal, EarlyView.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang, Jiying Li, Zhang Wang, Miao Yu, Chang Liu, Dongye Liu, Ruohan Wang   +6 more
wiley   +1 more source

Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data

Cell Reports, 2014
Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored.
Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda   +17 more
doaj   +1 more source

In vitro quality assessment of red blood cells and plasma units in DEHT/SAGM bags and DEHT/PAGGSM bags during storage

Vox Sanguinis, EarlyView.
Abstract Background and Objectives DEHT is considered a safer alternative to DEHP, a commonly used plasticizer with potential toxicological risks. We aimed to compare the storage efficacy of red blood cells (RBCs) in DEHT bags containing two different additive solutions: SAGM and PAGGSM.
Anaïs Lotens, Tome Najdovski, Nicolas de Valensart, Nicolas Cellier, Chryslain Sumian, Quentin Brebant, Christian Naegelen, Constant Cretenet, Nadine Marpaux   +8 more
wiley   +1 more source

Transcriptome pathways unique to dehydration tolerant relatives of modern wheat [PDF]

, 2009
Among abiotic stressors, drought is a major factor responsible for dramatic yield loss in agriculture. In order to reveal differences in global expression profiles of drought tolerant and sensitive wild emmer wheat genotypes, a previously deployed shock ...
AN Olsen, B Barnabas, B Vinocur, C Guy, D Bartels, DB Lobell, E Ormeno, EA Bray, G Toledo-Ortiz, GP Xue, GR Cramer, Hans J. Bohnert, HG Jones, Hikmet Budak, HJ Bohnert, IK Vasil, J Dubcovsky, J Zhou, JL Araus, Jyothi Thimmapuram, K Deuschle, K Higuchi, K Higuchi, K Poustini, K Shinozaki, L Cseke, L Rodriguez-Uribe, L Xiong, M Mohammadi, M Seki, MB Eisen, N Kaur, NC Collins, Neslihan Z. Ergen, O Cebeci, P Langridge, P Rampino, PBK Kishor, PY Muller, R Kaldenhoff, R Munns, S Chao, S Mahajan, S Ramanjulu, T Eulgem, The Gene Ontology Consortium, V Talame, W Li, W Wang, YG Shen, YH Lee, ZN Ergen, ZN Ergen, ZN Ozturk   +53 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

The Impact of the Natural Grass-Growing Model on the Development of Korla Fragrant Pear Fruit, as Well as Its Influence on Post-Harvest Sugar Metabolism and the Expression of Key Enzyme Genes Involved in Fruit Sugar Synthesis

Agriculture
In this study, the effects of natural grass cultivation and clear cultivation on the physiological characteristics of Korla fragrant pear during fruit development and storage were investigated, providing a scientific basis for high-quality fragrant pear ...
Mingyang Yu, Lanfei Wang, Yan Chen, Weifan Fan, Hao Wang, Kailu Guo, Shutian Tao, Xin Gong, Jianping Bao   +8 more
doaj   +1 more source

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source