Phosphofructokinase-1 Negatively Regulates Neurogenesis from Neural Stem Cells. [PDF]
Neurosci Bull, 2016 Phosphofructokinase-1 (PFK-1), a major regulatory glycolytic enzyme, has been implicated in the functions of astrocytes and neurons. Here, we report that PFK-1 negatively regulates neurogenesis from neural stem cells (NSCs) by targeting pro-neural transcriptional factors.
Zhang F +7 more
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Substrate antagonism in the kinetic mechanism of E. coli phosphofructokinase‐1 [PDF]
FEBS Letters, 1991 In the presence of its allosteric activator GDP, the major phosphofructokinase‐1 from Escherichia coli K12 follows Michaelis—Menten kinetics. The kinetic behavior observed at steady‐state using different concentrations of the substrates ATP and fructose‐6‐phosphate and the pattern of inhibition by the substrate analogs adenylyl‐(β,γ‐methylene ...
Dominique Deville‐Bonne +2 more
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PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP [PDF]
Biomarker ResearchLung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes ...
Félix Ritoré-Salazar +8 more
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Pharmacological ResearchPhenolic acid-rich fraction from Anisopus mannii (PhAM) contains abundance of ferulic acid, gallic acid, protocatechuic acid, and syringic acid.
Peter U. Amadi +13 more
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Protein phosphatase 4 dephosphorylates phosphofructokinase-1 to regulate its enzymatic activity. [PDF]
BMB Rep, 2023 Park J, Lee DH.
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Filament Assembly by Phosphofructokinase-1, the Gatekeeper of Glycolysis [PDF]
Biophysical Journal, 2014 The cytoskeleton is conventionally viewed as being composed of three filamentous networks; microfilaments, microtubules, and intermediate filaments. This view is challenged by the findings that metabolic enzymes can form filaments with structural functions.
Bradley A. Webb +2 more
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Role of Th1/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2, phosphofructokinase-1, and pyruvate kinase M2 in oral lichen planus [PDF]
Romanian Journal of Laboratory MedicineWe aimed to explore the role of T helper cell 1 (Th1)/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2 (HK2), phosphofructokinase-1 (PEK1) and pyruvate kinase M2 (PKM2) in oral lichen planus (OLP).
Yao Min +4 more
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Hitting the Sweet Spot: How Glucose Metabolism Is Orchestrated in Space and Time by Phosphofructokinase-1. [PDF]
Cancers (Basel), 2023 Campos M, Albrecht LV.
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Functional requirements of the liver isoform of phosphofructokinase-1 in breast cancer cell migration. [PDF]
J Cell SciHansen HL, Webb BA.
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Quantitative Analysis of the Effective Functional Structure in Yeast Glycolysis [PDF]
, 2011 Yeast glycolysis is considered the prototype of dissipative biochemical oscillators. In cellular conditions, under sinusoidal source of glucose, the activity of glycolytic enzymes can display either periodic, quasiperiodic or chaotic behavior. In order
Cortes, Jesus M. +1 more
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