Results 31 to 40 of about 204,096 (300)
A Role for Phosphoinositides in Regulating Plant Nuclear Functions
Frontiers in Plant Science, 2012 Nuclear localized inositol phospholipids and inositol phosphates are important for regulating many essential processes in animal cells such as DNA replication, recombination, RNA processing, mRNA export and cell cycle progression.
Catherine B Dieck +2 more
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Frontiers in Cell and Developmental Biology, 2020 Synucleinopathies are neurological disorders associated with α-synuclein overexpression and aggregation. While it is well-established that overexpression of wild type α-synuclein (α-syn-140) leads to cellular toxicity and neurodegeneration, much less is ...
Lindsey G. Soll +5 more
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Phosphoinositides and Photoreceptors [PDF]
Molecular Neurobiology, 2011 The importance of phosphoinositides (phosphorylated phosphatidyl inositol derivatives, PIs) for normal cellular function cannot be overstated. Although they represent a small fraction of the total phospholipid within the cell, they are essential regulators of many cellular functions.
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Phosphoinositides in New Spaces
Cold Spring Harbor Perspectives in Biology, 2023 Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are regulated via reversible phosphorylation, which is directed by the opposing actions of PI kinases and phosphatases. PIs constitute a minor fraction of the total cellular lipid pool but play pleiotropic roles in multiple aspects of cell biology.
Elizabeth Michele Davies +2 more
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eLife, 2016 Amyloid-β (Aβ)-containing extracellular plaques and hyperphosphorylated tau-loaded intracellular neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease (AD). Although Aβ exerts neuropathogenic activity through tau, the mechanistic
Tae-In Kam +7 more
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PI(3,4)P2 Signaling in Cancer and Metabolism
Frontiers in Oncology, 2020 The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer metabolism, and cancer cell proliferation.
Luca Gozzelino +4 more
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Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
Frontiers in Oncology, 2023 Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (
Yue Jin, Jian Xue
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Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
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Structural mechanisms of phospholipid activation of the human TPC2 channel
eLife, 2019 Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand ...
Ji She +5 more
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Phospholipids in Salt Stress Response
Plants, 2021 High salinity threatens crop production by harming plants and interfering with their development. Plant cells respond to salt stress in various ways, all of which involve multiple components such as proteins, peptides, lipids, sugars, and phytohormones ...
Xiuli Han, Yongqing Yang
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