Results 181 to 190 of about 27,357 (285)

A computational framework for the investigation of phosphoinositide regulation. [PDF]

PLoS Comput Biol
Cheung HYF, Tantiwong C, Kale D, Gibbins JM, Watson SP, Heemskerk JWM, Sickmann A, Ahrends R, Dunster JL.   +8 more
europepmc   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Ortho- and MetaPhenyl-Substituted Pyrrolo[2,1-f][1,2,4]triazine Derivatives as Novel Phosphoinositide 3-Kinase α Inhibitors

Sagar Patni, Ajay Kumar, Snehil Singh, Shashi Kiran Misra   +3 more
openalex   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Endosomal Trafficking and Phosphoinositide Signaling Distinguish Antidepressant Non-Remission from Symptom Improvement in a TWAS of NMN Aging-Rescue Pathways

Ngo Cheung
openalex   +2 more sources

Phosphoinositides in membrane remodeling during infections and cellular stresses. [PDF]

FEBS Lett
Alemany C, Morel E.
europepmc   +1 more source

Histopathology-guided multimodal pathomics identifies a PLEKHA6-positive epithelial state associated with phosphoinositide metabolism in esophageal cancer

Zhi Wang, Zhenjie Li, Nuo Yan, Wenxun Xiong, Weiqiang Feng, YunZhe Wang, Yiping Wei, Shengkai Huang   +7 more
openalex   +2 more sources

Laponite Network Controls FGF‐2 Release and Drives Functional Nerve Regeneration via 3D‐Printed Nerve Wrap Interfaces

Small Methods, EarlyView.
We developed a 3D‐printed nerve interface integrating a biomimetic nanocomposite hydrogel with sustained delivery of thermostable FGF‐2. The bioactive interface supports Schwann cell activity and myelination while providing a regenerative microenvironment.
Diego N. Rodriguez‐Sanchez, Akshat Joshi, Saeed Safari, Leticia A. M. de Carvalho, Kevin S. Muller, Uijin Kim, Luciana P. Cartarozzi, Meenakshi Kamaraj, Menekse Ermis, Natan R. de Barros, Alexandre L. R. de Oliveira   +10 more
wiley   +1 more source

Spatial organization of phosphoinositide signaling. [PDF]

FEBS Lett
Lai S, Huang W, He K.
europepmc   +1 more source

Nummular Dermatitis Following an Insect Bite in a Patient With Activated Phosphoinositide-3-Kinase Delta Syndrome (APDS): A Case Report and Literature Review

Adriana Hernandez-Carrasco, Irving Fuentes-Calvo, Sara Fernanda Arechavala-López, Valeria Hernandez-Carrasco, Yaara L. Soriano-Hernández, Arturo García-Galicia, Zaira Aketzali Contreras-Sánchez, Gabriela Carrasco-Trinidad   +7 more
openalex   +1 more source