A non-canonical activation of the host's ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani. [PDF]
Rosero J, Kima PE.
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PI3KC2β depletion rescues endosomal trafficking defects in Mtm1 knockout skeletal muscle cells. [PDF]
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A Chickpea NCR Peptide Suppresses Postharvest Alternaria alternata Infection by Disrupting Fungal Membranes, Mitochondria and Respiration. [PDF]
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Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities. [PDF]
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Conserved sequence features in intracellular domains of viral spike proteins. [PDF]
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A singular lipid composition supports the progression of plant autophagy
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Current Opinion in Cell Biology, 2002Phosphoinositides act as precursors of second messengers and membrane ligands for protein modules. Specific lipid kinases and phosphatases are located and differentially regulated in cell organelles, generating a non-uniform distribution of phosphoinositides.
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Cellular and Molecular Life Sciences, 2002Phosphoinositides comprise a family of eight minor membrane lipids which play important roles in many signal transducing pathways in the cell. Signaling through various phosphoinositides has been shown to mediate cell growth and proliferation, apoptosis, cytoskeletal changes, insulin action and vesicle trafficking.
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015The internalization and subsequent endosomal trafficking of proteins and membrane along the endocytic pathway is a fundamental cellular process. Over the last two decades, this pathway has emerged to be subject to extensive regulation by phosphoinositides (PIs), phosphorylated derivatives of the minor membrane phospholipid phosphatidylinositol ...
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Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
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