Results 221 to 230 of about 13,157 (254)

Phosphoinositides and the golgi complex

Current Opinion in Cell Biology, 2002
Phosphoinositides act as precursors of second messengers and membrane ligands for protein modules. Specific lipid kinases and phosphatases are located and differentially regulated in cell organelles, generating a non-uniform distribution of phosphoinositides.
Maria Antonietta De Matteis, Daniela Corda   +1 more
exaly   +3 more sources

The ubiquitous phosphoinositides

Biochemical Society Transactions, 2004
There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors and marking membrane compartments.
openaire   +3 more sources

Phosphoinositides and signal transduction

Cellular and Molecular Life Sciences, 2002
Phosphoinositides comprise a family of eight minor membrane lipids which play important roles in many signal transducing pathways in the cell. Signaling through various phosphoinositides has been shown to mediate cell growth and proliferation, apoptosis, cytoskeletal changes, insulin action and vesicle trafficking.
Alex Toker
exaly   +3 more sources

An Introduction to Phosphoinositides

2012
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This chapter describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells and introduces to some of their intracellular functions and to some evidences of their involvement in human
openaire   +2 more sources

Nuclear phosphoinositide signaling

Frontiers in Bioscience, 2008
Nuclear lipid metabolism performs a pivotal function in multiple signaling networks that mediate a variety of cellular events, including proliferation, differentiation and cell survival. The presence of phosphoinositides in the nuclei of mammalian cells is no longer in any doubt, and this has been corroborated by the detection of the enzymes ...
Keqiang, Ye, Jee-Yin, Ahn
openaire   +2 more sources

Phosphoinositide signalling in Drosophila

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Phosphoinositides (PtdInsPs) are lipids that mediate a range of conserved cellular processes in eukaryotes. These include the transduction of ligand binding to cell surface receptors, vesicular transport and cytoskeletal function. The nature and functions of PtdInsPs were initially elucidated through biochemical experiments in mammalian cells. However,
Sruthi S, Balakrishnan, Urbashi, Basu, Padinjat, Raghu   +2 more
openaire   +2 more sources

Phosphoinositide metabolism and oncogenes

Clinica Chimica Acta, 1989
The hydrolysis of phosphatidylinositol 4,5-bisphosphate plays important roles in growth factor- or oncogene-induced cell proliferation. However, it is still unknown whether the hydrolysis of phosphatidylinositol 4,5-bisphosphate is an essential step for cell growth. To solve this problem, we developed a monoclonal antibody against the lipid.
T, Takenawa, K, Fukami
openaire   +2 more sources

Phosphoinositides in phagocytosis and macropinocytosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Professional phagocytes provide immunoprotection and aid in the maintenance of tissue homeostasis. They perform these tasks by recognizing, engulfing and eliminating pathogens and endogenous cell debris. Here, we examine the paramount role played by phosphoinositides in phagocytosis and macropinocytosis, two major endocytic routes that mediate the ...
Roni, Levin, Sergio, Grinstein, Daniel, Schlam   +2 more
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Assaying Phosphoinositide Phosphatases

2004
The roles of phosphoinositide second messengers as signaling molecules in a vast array of cellular processes including cell growth, metabolism, vesicular transport, programmed cell death, and responses to extracellular signals are only beginning to be understood.
Gregory S, Taylor, Jack E, Dixon
openaire   +2 more sources

Pathways for phosphoinositide synthesis

Chemistry and Physics of Lipids, 1999
In eukaryotic cells, phosphatidylinositol can be phosphorylated on the inositol ring by a series of kinases to produce at least seven distinct phosphoinositides. These lipids have been implicated in a variety of cellular processes, including calcium regulation, actin rearrangement, vesicle trafficking, cell survival and mitogenesis.
K F, Tolias, L C, Cantley
openaire   +2 more sources