Results 221 to 230 of about 13,190 (254)

Assaying Phosphoinositide Phosphatases

2004
The roles of phosphoinositide second messengers as signaling molecules in a vast array of cellular processes including cell growth, metabolism, vesicular transport, programmed cell death, and responses to extracellular signals are only beginning to be understood.
Gregory S, Taylor, Jack E, Dixon
openaire   +2 more sources

Pathways for phosphoinositide synthesis

Chemistry and Physics of Lipids, 1999
In eukaryotic cells, phosphatidylinositol can be phosphorylated on the inositol ring by a series of kinases to produce at least seven distinct phosphoinositides. These lipids have been implicated in a variety of cellular processes, including calcium regulation, actin rearrangement, vesicle trafficking, cell survival and mitogenesis.
K F, Tolias, L C, Cantley
openaire   +2 more sources

Phosphoinositides and Cellular Pathogens

2012
Phosphoinositides are considered as highly dynamic players in the spatiotemporal organization of key signaling pathways, actin cytoskeleton rearrangements, establishment of cell polarity and intracellular vesicle trafficking. Their metabolism is accurately controlled and mutations in several phosphoinositide metabolizing enzymes take part in the ...
Payrastre, Bernard, Gaits-Iacovoni, Frédérique, Sansonetti, Philippe, Tronchère, Hélène   +3 more
openaire   +2 more sources

Phosphoinositides and cell proliferation

Journal of Cell Science, 1985
ABSTRACT Certain growth factors act by stimulating the hydrolysis of inositol lipids to yield putative second messengers such as diacylglycerol (DG) and inositol trisphosphate (IP3). One function of the former is to stimulate C-kinase, which may act by switching on a sodium/hydrogen exchanger to induce the increase in pH that appears to ...
M J, Berridge, K D, Brown, R F, Irvine, J P, Heslop   +3 more
openaire   +2 more sources

Phosphoinositide Recognition Domains

Traffic, 2003
Domains or modules known to bind phosphoinositides have increased dramatically in number over the past few years, and are found in proteins involved in intracellular trafficking, cellular signaling, and cytoskeletal remodeling. Analysis of lipid binding by these domains and its structural basis has provided significant insight into the mechanism of ...
openaire   +2 more sources

Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Chemical Reviews, 2001
N R, Leslie, R M, Biondi, D R, Alessi
openaire   +2 more sources

Nuclear Phosphoinositides and Their Functions

2004
Phosphoinositides are minor components of biological membranes, which have emerged as essential regulators of a variety of cellular processes, both on the plasma membrane and on several intracellular organelles. The versatility of these lipids stems from their ability to function either as substrates for the generation of second messengers, as membrane-
G, Hammond, C L, Thomas, G, Schiavo
openaire   +2 more sources

Phosphoinositides and Synaptic Transmission

1996
The isolation of a “diphosphoinositide” fraction from ox brain by Folch (1949) and the observation by Dawson (1954) that radioactive phosphate was rapidly incorporated into its lipids laid the foundations of our present knowledge of the brain phosphoinositides.
openaire   +2 more sources

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Cell, 2022
Brian Kobilka, John Janetzko
exaly  

Phosphoinositides

2012
Anne M. Heacock, Stephen K. Fisher
  +4 more sources