Results 211 to 220 of about 13,157 (254)

Small current, big potential: bridging mechanistic insight of the SK channel with translational promise

open access: yes
The Journal of Physiology, EarlyView.
Yang Zheng   +2 more
wiley   +1 more source

Phosphoinositides in endocytosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
The internalization and subsequent endosomal trafficking of proteins and membrane along the endocytic pathway is a fundamental cellular process. Over the last two decades, this pathway has emerged to be subject to extensive regulation by phosphoinositides (PIs), phosphorylated derivatives of the minor membrane phospholipid phosphatidylinositol ...
York Posor   +2 more
openaire   +2 more sources

Phosphoinositide kinases

Current Opinion in Cell Biology, 1990
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
openaire   +3 more sources

THE CHEMISTRY OF THE PHOSPHOINOSITIDES

Canadian Journal of Biochemistry and Physiology, 1956
The name of inositol phosphatides or phosphoinositides is given to a rather heterogeneous group of substances having in common the presence of inositol, phosphoric acid, and fatty acid(s) among their constituents. The first evidence of their natural occurrence was obtained by Anderson, in 1930, who showed their presence in the lipides of the tubercle ...
J, FOLCH, F N, LEBARON
openaire   +2 more sources

Phosphoinositide Signaling

Annual Review of Plant Biology, 2012
All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying
Wendy F, Boss, Yang Ju, Im
openaire   +2 more sources

The Brain Phosphoinositides

1964
Publisher Summary This chapter focuses on brain phosphoinositides. Diphosphoinositide occurs in mitochondria of tissues other than brain and is rapidly labeled in vitro under conditions suitable for oxidative phosphorylation. This adds considerably to the significance of the brain phosphoinositides from a biochemical point of view. The earlier work
J N, Hawthorne, P, Kemp
openaire   +2 more sources

Phosphoinositides in Chemotaxis

2012
Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array of biological responses. In particular, their role in the regulation of cell migration has been extensively studied and extends to amoeboid as well as mesenchymal migration.
Michael C, Weiger, Carole A, Parent
openaire   +2 more sources

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