Results 211 to 220 of about 13,190 (254)
Some of the next articles are maybe not open access.
THE CHEMISTRY OF THE PHOSPHOINOSITIDES
Canadian Journal of Biochemistry and Physiology, 1956The name of inositol phosphatides or phosphoinositides is given to a rather heterogeneous group of substances having in common the presence of inositol, phosphoric acid, and fatty acid(s) among their constituents. The first evidence of their natural occurrence was obtained by Anderson, in 1930, who showed their presence in the lipides of the tubercle ...
J, FOLCH, F N, LEBARON
openaire +2 more sources
Annual Review of Plant Biology, 2012
All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying
Wendy F, Boss, Yang Ju, Im
openaire +2 more sources
All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying
Wendy F, Boss, Yang Ju, Im
openaire +2 more sources
1964
Publisher Summary This chapter focuses on brain phosphoinositides. Diphosphoinositide occurs in mitochondria of tissues other than brain and is rapidly labeled in vitro under conditions suitable for oxidative phosphorylation. This adds considerably to the significance of the brain phosphoinositides from a biochemical point of view. The earlier work
J N, Hawthorne, P, Kemp
openaire +2 more sources
Publisher Summary This chapter focuses on brain phosphoinositides. Diphosphoinositide occurs in mitochondria of tissues other than brain and is rapidly labeled in vitro under conditions suitable for oxidative phosphorylation. This adds considerably to the significance of the brain phosphoinositides from a biochemical point of view. The earlier work
J N, Hawthorne, P, Kemp
openaire +2 more sources
Phosphoinositides in Chemotaxis
2012Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array of biological responses. In particular, their role in the regulation of cell migration has been extensively studied and extends to amoeboid as well as mesenchymal migration.
Michael C, Weiger, Carole A, Parent
openaire +2 more sources
The ubiquitous phosphoinositides
Biochemical Society Transactions, 2004There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors and marking membrane compartments.
openaire +3 more sources
An Introduction to Phosphoinositides
2012Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This chapter describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells and introduces to some of their intracellular functions and to some evidences of their involvement in human
openaire +2 more sources
Nuclear phosphoinositide signaling
Frontiers in Bioscience, 2008Nuclear lipid metabolism performs a pivotal function in multiple signaling networks that mediate a variety of cellular events, including proliferation, differentiation and cell survival. The presence of phosphoinositides in the nuclei of mammalian cells is no longer in any doubt, and this has been corroborated by the detection of the enzymes ...
Keqiang, Ye, Jee-Yin, Ahn
openaire +2 more sources
Phosphoinositide signalling in Drosophila
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015Phosphoinositides (PtdInsPs) are lipids that mediate a range of conserved cellular processes in eukaryotes. These include the transduction of ligand binding to cell surface receptors, vesicular transport and cytoskeletal function. The nature and functions of PtdInsPs were initially elucidated through biochemical experiments in mammalian cells. However,
Sruthi S, Balakrishnan +2 more
openaire +2 more sources
Phosphoinositide metabolism and oncogenes
Clinica Chimica Acta, 1989The hydrolysis of phosphatidylinositol 4,5-bisphosphate plays important roles in growth factor- or oncogene-induced cell proliferation. However, it is still unknown whether the hydrolysis of phosphatidylinositol 4,5-bisphosphate is an essential step for cell growth. To solve this problem, we developed a monoclonal antibody against the lipid.
T, Takenawa, K, Fukami
openaire +2 more sources
Phosphoinositides in phagocytosis and macropinocytosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015Professional phagocytes provide immunoprotection and aid in the maintenance of tissue homeostasis. They perform these tasks by recognizing, engulfing and eliminating pathogens and endogenous cell debris. Here, we examine the paramount role played by phosphoinositides in phagocytosis and macropinocytosis, two major endocytic routes that mediate the ...
Roni, Levin +2 more
openaire +2 more sources