Results 241 to 250 of about 27,357 (285)

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Endosomal TPC1-mediated Ca²⁺ nanodomains regulate transferrin receptor trafficking and iron homeostasis. [PDF]

Proc Natl Acad Sci U S A
Burton WJ, Lin A, Morgan AJ, Davis LC, Chen CC, Galione A.   +5 more
europepmc   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Nuclear PI3P produced by the Beclin-1/Vps34 complex regulates DNA mismatch repair. [PDF]

Nucleic Acids Res
Li X, Vicinanza M, Lopez A, Festa BP, Schlotawa L, Barbosa AD, Takla M, Balmus G, Fleming A, Rubinsztein DC.   +9 more
europepmc   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK. [PDF]

Biochem Soc Trans
Shaw AL, Burke JE.
europepmc   +1 more source

Corrigendum to “Natural history of clinical manifestations in activated phosphoinositide 3-kinase δ syndrome (APDS): Time-to-event analyses using the European Society for Immunodeficiencies-APDS registry” [Clinical Immunology 283 (2025) 110632]

Maria Elena Maccari, Sven Kracker, Anita Chandra, Stephan R. Ehl, Markus G. Seidel, Joanne Tutein Nolthenius, Laura J. Clark, Jennifer Page, Annabel Griffiths, John Whalen   +9 more
openalex   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Inositol and PIP2/PIP3 Ratio: At the Crossroad of the Biodynamic Interface Between Cells and Their Microenvironment. [PDF]

Biomolecules
Lentini G, Querqui A, Giuliani A, Verna R, Bizzarri M.   +4 more
europepmc   +1 more source

Phosphoinositide turnover through PLCγ regulates Draper-dependent engulfment in glia

Freya Storer, Eilish Mackinnon, Hannah Clarke, Daniel C. Maddison, Leonardo Amadio, Thejaswini Susobhanan, Bilal R. Malik, Owen M. Peters, Gaynor Ann Smith   +8 more
openalex   +1 more source