Results 161 to 170 of about 13,157 (254)

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Inositol and PIP2/PIP3 Ratio: At the Crossroad of the Biodynamic Interface Between Cells and Their Microenvironment. [PDF]

Biomolecules
Lentini G, Querqui A, Giuliani A, Verna R, Bizzarri M.   +4 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Correction: Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. [PDF]

Biochem J
europepmc   +1 more source

Unraveling the role of amphisomes in mast cell secretory granule fusion and exosome release. [PDF]

Extracell Vesicles Circ Nucl Acids
Tsilioni I.
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Bon appétit, your phagocyte. [PDF]

Cell Death Discov
Ozkocak DC, Santavanond JP, Tanzer MC, Poon IKH.   +3 more
europepmc   +1 more source

A novel adaptor protein, ARAP, orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF‐κB‐mediated cytokine production

Immunology &Cell Biology, EarlyView.
ARAP selectively regulates FcγR‐mediated signaling in dendritic cells. Loss of ARAP impairs phosphorylation of key signaling proteins, Rap1 activation, and integrin‐mediated adhesion, as well as NF‐κB p65 nuclear translocation and downstream cytokine production.
Chohee Park, Mi Jin Yu, Jong Ran Lee
wiley   +1 more source

Optimizing PH Domain-Based Biosensors for Improved Plasma Membrane PIP₃ Measurements in Mammalian Cells. [PDF]

Cells
Damouni A, Tóth DJ, Schönek A, Kasbary A, Boros AP, Várnai P.   +5 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source