Results 161 to 170 of about 27,357 (285)

Phosphoinositide-dependent signaling in arteriovenous fistula remodeling and failure: From pathophysiology to emerging therapeutic targets

Stefano Leto, Giulia Valastro, Eleonora Ceneri, Raffaella Mauro, Chiara Mascoli, Mauro Gargiulo, Lucia Manzoli, Lucio Cocco, Roberta Fiume, Stefano Ratti   +9 more
openalex   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

The lipid-binding PX domain of RRC-1 (ARHGAP32/33) is required for optimal assembly and function of integrin adhesion complexes at the muscle cell boundary in C. elegans. [PDF]

G3 (Bethesda)
Sagadiev S, Martin I, Arefeayne N, Wang Y, Hudson R, Mayans O, Qadota H, Benian GM.   +7 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Why Do Cells Contain Thousands of Lipid Species? Toward an Integrated Framework for Lipid Diversity in Biological Membranes. [PDF]

Int J Mol Sci
Kim KH, Yoo BC.
europepmc   +1 more source

Gut microbiota derived butyrate suppresses colorectal cancer via phosphoinositide three kinase and protein kinase B signaling

Yu Ge, Long Qian, Wen Jiang, Lei Zheng, Jin Wang, Mao-Kun Feng, Yi-Mei Zhu, Meng-Jun Wang, Sha-Sha Sun, 芮景, Mao-Qi Xu   +10 more
openalex   +2 more sources

Systematic discovery of novel phosphoinositide-binding effectors in Legionella reveals conserved ɑ-helical folds [PDF]

Abigail Bolt, Abby E. Richardson, Colleen M. Pike, Rebecca R. Noll, Yanbao Yu, Joshua P. Neunuebel, Sylvain Le Marchand, Karl R. Schmitz, M. Ramona Neunuebel   +8 more
openalex   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Editorial: Lipid regulation in plants: a spatiotemporal approach to environmental stress adaptation. [PDF]

Front Plant Sci
Cho Y, Lin YC.
europepmc   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source