Results 121 to 130 of about 369,030 (389)

Phospholipase Cβ2 Binds to and Inhibits Phospholipase Cδ1 [PDF]

Journal of Biological Chemistry, 2005
Phospholipase Cβ (PLCβ) isoforms, which are under the control of Gαq and Gβγ subunits, generate Ca2+ signals induced by a broad array of extracellular agonists, whereas PLCδ isoforms depend on a rise in cytosolic Ca2+ for their activation. Here we find that PLCβ2 binds strongly to PLCδ1 and inhibits its catalytic activity in vitro and in living cells ...
Mario J. Rebecchi, Yuanjian Guo, Suzanne Scarlata   +2 more
openaire   +2 more sources

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Soybean Oil Degumming by Immobilized Phospholipase A1 [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
In the present study, we investigated the ability of an immobilized phospholipase A1 (PLA1) in degumming of soybean oil. The enzyme was immobilized by simple adsorption on bentonite without any further modification.
Redha Kernani, Abdelhamid Boukerroui
doaj  

Synergistic Antifungal Effect of Fluconazole Combined with Licofelone against Resistant Candida albicans

Frontiers in Microbiology, 2017
Candida albicans (C. albicans) is one of the important opportunistic fungal pathogens that is closely associated with disseminated or chronic infections. The objective of this study is to evaluate the synergistic antifungal effect of licofelone, which is
Xinning Liu, Xinning Liu, Tao Li, Decai Wang, Yilei Yang, Wenwen Sun, Jianqiao Liu, Shujuan Sun   +7 more
doaj   +1 more source

The effect of experimental hyperoxia on erythrocytes’ oxygen-transport function [PDF]

, 2018
The aim of this study was to investigate the effect of hyperoxia, calcium ions and pH value on the composition of major phospholipids in human erythrocyte membranes and erythrocytes’ oxygen-transport function. To create a model of hyperoxia, we saturated
Alexander Alexandrovich Moskovkin, Alexander Yurievich Tychkov, Anastasia Nikolaevna Kukina, Anastasia Yurievna Samonova, Bligh EA, Borza C, Dobrotyna NA, Drgová A, Elvira Sergeevna Revina, Gavrilov VB, Gavrilov VB, Igor Pavlovich Grunyushkin, Jean-Christophe Bourdon, Litvitskiy PF, Marangoni AG, Marinetti GV, Morrison WR, Natalia Vasilevna Gromova, Nikolai Zhelev, Novitskiy VV, Sikorski AF, Takakuwa Y, Vasil'yeva YEM, Vercaеmst L, Victor Vasilevich Revin, Vlasov AP   +25 more
core   +3 more sources

Phospholipase A Activity in the Epidermis

Journal of Investigative Dermatology, 1972
Phospholipase A activity has been demonstrated in cow snout epidermis. The activity was higher in the upper layers of the epidermis. The enzyme has been purified by preparing aqueous extracts of acetone powders obtained from epidermal homogenates. The most active preparation gave a pH optimum of 8.3 for the release of free fatty acids from phosphatidyl
V.J.W. Long, H.J. Yardley
openaire   +3 more sources

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source