Results 81 to 90 of about 166,829 (294)

Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation

Marine Drugs, 2016
Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases.
Chun-Yu Chen, Yung-Fong Tsai, Wen-Yi Chang, Shun-Chin Yang, Tsong-Long Hwang   +4 more
doaj   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

A 90-kD Phospholipase D from Tobacco Binds to Microtubules and the Plasma Membrane [PDF]

, 2001
John Gardiner, John Harper, N. D. Weerakoon, David A. Collings, Siân Ritchie, Simon Gilroy, Richard J. Cyr, Jan Marc   +7 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Special Issue: Novel Antifungal Drug Discovery

Journal of Fungi, 2016
This Special Issue is designed to highlight the latest research and development on new antifungal compounds with mechanisms of action different from the ones of polyenes, azoles, and echinocandins.
Maurizio Del Poeta
doaj   +1 more source

Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A2 Homologue [PDF]

, 2019
Charles Nunes Boeno, Mauro Valentino Paloschi, Jéssica Amaral Lopes, Weverson Luciano Pires, Sulamita da Silva Setúbal, Jaína Rodrigues Evangelista, Andreimar M. Soares, Juliana Pavan Zuliani   +7 more
openalex   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Molecular identification and extracellular enzyme production of Rhodotorula spp.

Italian Journal of Mycology
Rhodotorula spp. have been associated with human infections, particularly in individuals with weakened immune systems. This study aimed to identify 31 isolates of Rhodotorula spp. recovered from coin-operated washing machines.
Potjaman Pumeesat, Laongdaw Nasom, Kornkanok Thongdee, Tawanwat Damnak, Tanaporn Sirikhetkorn, Paphichaya Unwong, Sopida Benjamat, San Suwanmanee, Thanwa Wongsuk   +8 more
doaj   +1 more source

Retraction: Activation of cytosolic phospholipase A2α through nitric oxide-induced S-nitrosylation. INVOLVEMENT OF INDUCIBLE NITRIC-OXIDE SYNTHASE AND CYCLOOXYGENASE-2. [PDF]

, 2015
Lihong Xu, Chang Han, Kyu Lim, Tong Wu
openalex   +1 more source