ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Formation of Prostaglandin Cyclo-Peroxides and Prostaglandins by Phospholipase A2 in Platelets of Normal and Essential Fatty Acid Deficient Rats [PDF]
, 1977 J. Vincent, Freek J. Zijlstra
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Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Revista Peruana de Medicina Experimental y Salud Pública, 2012 Objetivos. Estudiar la variabilidad en la composición y actividades enzimáticas entre venenos de ejemplares adultos de Bothrops atrox. Materiales y métodos. Se emplearon venenos de serpientes adultas procedentes de Amazonas, Junín y Ucayali.
César Ortiz +4 more
doaj
Net activity of phospholipase A2 in brain and the lack of stimulation of the phospholipase A2-acylation stem [PDF]
, 1977 C. E. Rowe
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Entomologia Experimentalis et Applicata, Volume 173, Issue 7, Page 708-723, July 2025.We investigated the molecular basis of host switching by the phytophagous West Indian fruit fly (A. obliqua). Third‐instar larvae showed differential gene expression according to host plants: red mombin, mango, and carambola. The main gene categories differentially expressed were digestion, detoxification, and gene regulators.
Sandra M. Velasco‐Cuervo +5 more
wiley +1 more source
Human Prothrombin/Phospholipids Interaction. Competitive Effect of an Anticoagulant Venom Phospholipase A2 [PDF]
, 1977 G. A. Boffa, Richard Benarous, M C Boffa
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Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities
Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.ABSTRACT Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic.
Callum N. Atkins +2 more
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Journal of Pharmacological Sciences, 2011 Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated.
Yoshiyuki Tanabe +6 more
doaj
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells. [PDF]
, 1986 Ronald M. Burch +2 more
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