Results 91 to 100 of about 343,412 (268)

The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans [PDF]

open access: yes, 2014
This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17.
Brooke, Matthew A
core   +2 more sources

Fatty acid and phospholipase A2 plasma levels in children with autism Níveis plasmáticos de ácidos graxos e fosfolipase A2 em crianças com autismo

open access: yesTrends in Psychiatry and Psychotherapy, 2013
OBJECTIVE: To evaluate fatty acid plasma levels, phospholipase A2 activity, and the developmental profiles of children with autism vs. control subjects. METHODS: Twenty four children with autism underwent laboratory analysis for fatty acid quantification
Márcia Helena Fávero de Souza Tostes   +5 more
doaj  

Lipidomic data on lipid droplet triglyceride remodelling associated with protection of breast cancer cells from lipotoxic stress

open access: yesData in Brief, 2018
The data presented here is related to the research article entitled “Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress” by E. Jarc et al., Biochim. Biophys. Acta
Eva Jarc   +3 more
doaj   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens

open access: yesAnais da Academia Brasileira de Ciências, 2015
In this work, we used the Minimum Inhibitory Concentration (MIC) technique to evaluate the antibacterial potential of the apitoxin produced by Apis mellifera bees against the causative agents of tooth decay.
Luís F. Leandro   +6 more
doaj   +1 more source

Protective Effects of Bee Venom (Apis mellifera) Against Cadmium‐Induced Hepatorenal Toxicity, Oxidative Stress, and Anxiety‐Like Behavior in Rats

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a persistent environmental heavy metal and a major public health concern because it persists in the body for long periods and gradually accumulates in vital organs, particularly the liver, kidneys, and brain. Chronic Cd exposure promotes the excessive production of reactive oxygen species (ROS), which ultimately leads to ...
Soumaya Ghodbane   +8 more
wiley   +1 more source

Lipoprotein-associated phospholipase A2, vascular inflammation and cardiovascular risk prediction

open access: yes, 2006
Krishnankutty SudhirStanford University Medical Center, Stanford, CA, USAAbstract: Circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of inflammation that plays a critical role in atherogenesis; its inhibition may have ...
Krishnankutty Sudhir
core  

Mechanism(s) of activation of secretory phospholipase A2s in mouse keratinocytes

open access: yesJournal of Lipid Research, 1999
The differential activation of different members of the phospholipase A2 (PLA2) superfamily and their regulation are important as one or more of them regulates the production of eicosanoids and others may contribute to the formation of other lipid ...
Bangyan Li-Stiles, Susan M. Fischer
doaj   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng   +3 more
wiley   +1 more source

The hydrolysis of phosphatidylcholine by phospholipase A2 in hamster heart

open access: yes, 1984
The hydrolysis of acyl esters in phosphatidylcholine and phosphatidylethanolamine by phospholipase A in hamster heart subcellular fractions was investigated.
Man, RYK, Choy, PC, Tam, SW
core   +1 more source

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