Results 81 to 90 of about 343,412 (268)

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Correlation Between Lipoprotein-Related Phospholipase A2 and Metabolic Syndrome

, 2023
Kai-Yu Wang,1 Yi-Chuan Chen,1,2 Jau-Yuan Chen,1,2 Song-Seng Loke,3 Wei-Chung Yeh,4 Wen-Cheng Li1,2,5 1Department of Family Medicine, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 2College of Medicine, Chang Gung University, Taoyuan, Taiwan ...
Li WC, Loke SS, Chen YC, Wang KY, Chen JY, Yeh WC   +5 more
core  

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL

Journal of Lipid Research, 1998
Group IIA secretory phospholipase A2 is an acute phase enzyme, co-expressed with serum amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal and acute phase high density lipoproteins and low density lipoprotein are ...
Waldemar Pruzanski, Eva Stefanski, Frederick C. de Beer, Maria C. de Beer, Peter Vadas, Amir Ravandi, Arnis Kuksis   +6 more
doaj   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Phospholipase A2 Activity Modulates “Ischemic Effect” in Pig Skin [PDF]

, 1983
The level of cyclic AMP in the epidermis rapidly increase within 15 min after separation from the in vivo condition. This phenomenon is the so-called “ischemic effect.” In order to elucidate the possible mechanism of the ischemic effect, the effects of ...
Miura, Yusho, Nemoto, Osamu, Aoyagi, Takashi   +2 more
core   +1 more source

Study of the influence of various physiologically active substances on changes in the lipid composition and phospholipase activity of damaged somatic nerves [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология
The changes in lipid composition and phospholipase activity in damaged somatic nerves were studied against the background of the action of potassium hyaluronate and insulin-like growth factor-1.
Revin, Viktor V., Parchaykina, Marina V., Chudaikina, Elena V., Revina, Elvira S., Molchanov, Ivan D., Simakova, Milena A., Zavarykina, Anastasia Vyacheslavovna, Grunyushkin, Igor P., Devyatkin, Arkadiy А.   +8 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Correlation between phospholipase A2 activity and intra-Golgi protein transport reconstituted in a cell-free system [PDF]

, 1993
A wide variety of phospholipase A2 inhibitors blocks intra-Golgi protein transport reconstituted in a cell-free system. Phospholipase A2 activity detectable under the protein transport assay conditions is actually inhibited by the inhibitors.
Akitsugu Yamamoto, Yutaka Tashiro, Yamamoto, Akitsugu, Tagaya, Mitsuo, Nobuhiro Henomatsu, Tashiro, Yutaka, Mitsuo Tagaya, Yoshimori, Tamotsu, Fukui, Toshio, Tamotsu Yoshimori, Toshio Fukui, Henomatsu, Nobuhiro   +11 more
core   +1 more source

Producing Monoclonal Antibodies To Phospholipase A2 [PDF]

, 1985
Monoclonal antibodies were produced to phospholipase A2, a protein allergen of honey bee venom. The hybridoma technique, which involves fusing antibody-producing spleen cells to myeloma cells was used.
Kernie, Marie
core   +2 more sources