Results 61 to 70 of about 67,252 (282)

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Phospholipase A2 Activates Hemostasis

Drug Target Insights, 2007
Background: Phospholipases A2 (PLA2) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief
doaj  

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

Anais da Academia Brasileira de Ciências, 2013
The Streptoverticillium sp. Z1 is an actinomycete isolated from the soil under Cerrado vegetation, the extract of this strain was investigated in nociceptive and inflammatory models.
RODRIGO B. DA CRUZ, PABLINNY M. GALDINO, KARLLA G.B.D. PENNA, KAREN HOFFMANN, ELSON A. COSTA, LUIZ A.M. BATAUS   +5 more
doaj   +1 more source

Bee venom enhances dopaminergic function and behavioral recovery in a murine model of Parkinson's disease

Neuroprotection, EarlyView.
Experimental design and behavioral outcomes of bee venom treatment in a murine model of Parkinson's disease. Mice received an intrastriatal injection of 6‐OHDA into the right hemisphere to induce dopaminergic degeneration. Animals were subsequently treated with l‐DOPA/carbidopa, with or without bee venom (BV) administered intraperitoneally.
Silvia Josefina López‐Pérez, Marco Antonio Noriega‐Ruiz, Alma Karen Lomeli‐Lepe   +2 more
wiley   +1 more source

Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor

Journal of Pharmacological Sciences, 2011
Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated.
Yoshiyuki Tanabe, Maki Saito, Yuki Morikawa, Akihisa Kamataki, Takashi Sawai, Masamichi Hirose, Koichi Nakayama   +6 more
doaj   +1 more source

Lysosomal Phospholipase A2 and Phospholipidosis [PDF]

Molecular and Cellular Biology, 2006
A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2. LPLA2-deficient mice (Lpla2-
Hiraoka, Miki, Abe, Akira, Lu, Ye, Yang, Kui, Han, Xianlin, Gross, Richard, Shayman, James A   +6 more
openaire   +3 more sources

x‐Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca2+‐Stabilized Expanded Active‐Site Cleft Adapted for Phospholipid Binding

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to generate phosphatidic acid and free head groups such as choline. Among bacterial PLD enzymes, Streptomyces chromofuscus PLD (SchPLD), a member of the alkaline phosphatase D (PhoD) superfamily, exhibits unique Ca2+‐dependent phospholipase activity.
Yoshiaki Yasutake, Tatsuya Hirata, Shunsuke Nomura, Kenji Konishi, Kazunari Yoneda, Shin‐ichi Sakasegawa, Haruhiko Sakuraba   +6 more
wiley   +1 more source

Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2013
The enzymes belonging to the cutinase family are serine enzymes active on a large panel of substrates such as cutin, triacylglycerols, and phospholipids. In the M.
Luc Dedieu, Carole Serveau-Avesque, Stéphane Canaan   +2 more
doaj   +1 more source