Results 61 to 70 of about 315,246 (280)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ladds, Graham, Aletrari, Mina-Olga, Hodgkin, Matthew N., Farquhar, Michelle J., Wright, Michelle H.   +4 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor–negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus

Journal of International Medical Research
Background Neural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults.
Qingqing Rao, Yuan Cheng, Shuling Yue, Haiying Song, Wangyang Li, Dongli Qi, Qijun Wan   +6 more
doaj   +1 more source

Differential determination of phospholipase A2 and PAF-acetylhydrolase in biological fluids using fluorescent substrates

Journal of Lipid Research, 1999
The purpose of the present study was the development and evaluation of a fluorimetric method for the screening and differential determination of phospholipase A2 and PAF-acetylhydrolase in bronchoalveolar lavage (BAL) fluid and serum.
Eirini I. Kitsiouli, George Nakos, Marilena E. Lekka   +2 more
doaj   +1 more source

Phospholipase A2 and Phospholipase B activities in fungi [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source.
Gerwald A, Köhler, Audrey, Brenot, Eric, Haas-Stapleton, Nina, Agabian, Rupal, Deva, Santosh, Nigam   +5 more
openaire   +2 more sources

Involvement of axonal phospholipase A2 activity in the outgrowth of adult mouse sensory axons in vitro

, 1999
The effect on axonal outgrowth of inhibition of phospholipase A2 activity was studied in a recently developed in vitro model, where dorsal root ganglia with attached spinal roots and nerve stumps from young adult mice were cultured in an extracellular ...
Ekström, Per, Hornfelt, M., Edström, A., A Edström, P.A.R Ekström, M Hornfelt, Ekström, Per,, Lund University., Hornfelt, M.,   +8 more
core   +1 more source

Protein engineering of phospholipase A2: A model to study membrane-protein interactions.

, 1995
Protein engineering of phospholipase A2: A model to study membrane-protein ...
Rajiv. Dua (7984808)
core   +3 more sources

Phospholipase A2 Activates Hemostasis

Drug Target Insights, 2007
Background: Phospholipases A2 (PLA2) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief
doaj  

Regulation of group IVA cytosolic phospholipase A2 by multiple sites phosphorylation.

, 2008
Regulation of group IVA cytosolic phospholipase A2 by multiple sites ...
Wen. Tian (7966331)
core   +3 more sources