Results 51 to 60 of about 315,246 (280)

Oncogenic action of phospholipase A2 in prostate cancer

, 2006
Mortality from prostate cancer is a result of progression of cancer cells to become androgen-refractory and metastatic. Eicosanoid products of the cyclooxygenase (COX) and lipoxygenase (LOX) pathways are important mediators of the proliferation of ...
Sved, Paul, Scott, Kieran F., Scott, Kieran, Patel, Manish, Russell, Pamela, Dong, Qihan, Graham, Garry G., Graham, Garry, Russell, Pamela J.   +8 more
core   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Economic Benefit of Anti-PLA2R Antibody Testing in the Diagnosis of Membranous Nephropathy: A Single-Center Cost Analysis

Turkish Journal of Nephrology
Background: This study aimed to evaluate the financial impact of using anti-phospholipase A2 receptor antibody testing instead of kidney biopsy for diagnosing membranous nephropathy.
Asil Demirezen, Nuri Alperen Malkoç, Ömer Faruk Akçay, Saliha Yıldırım, Emre Yaşar, Sena Türkmen, Emre Yaşar, Sena Türkmen, Özlem Gülbahar, Betül Öğüt, İpek Işık Gönül, Galip Güz, Ülver Derici, Yasemin Erten, Kadriye Altok, Özant Helvacı   +15 more
doaj   +1 more source

Phospholipase A2 Receptor Antibody IgG4 Subclass Improves Sensitivity and Specificity in the Diagnosis of Idiopathic Membranous Nephropathy

Kidney & Blood Pressure Research, 2019
Aims: The aim of this study was to develop a new method for detecting anti-phospholipase A2 receptor-IgG4 to improve the sensitivity and specificity in the diagnosis of idiopathic membranous nephropathy (IMN).
Biao Huang, Yi Zhang, Liang Wang, Wenwei Xu, Jue Zhang, Qiuhua Zhang, Huiming Sheng, Zhigang Hu   +7 more
doaj   +1 more source

Phospholipase A2 Activity Modulates “Ischemic Effect” in Pig Skin

, 1983
The level of cyclic AMP in the epidermis rapidly increase within 15 min after separation from the in vivo condition. This phenomenon is the so-called “ischemic effect.” In order to elucidate the possible mechanism of the ischemic effect, the effects of ...
Miura, Yusho, Nemoto, Osamu, Aoyagi, Takashi   +2 more
core   +1 more source

Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana, Yiwen Li, Braulio Carrillo Sanchez, Ayesha Khan, Paul A. Dalby   +4 more
wiley   +1 more source

A Green Protocol for the Deprotection of ortho‐Nitrobenzyl Esters and Ethers by UVA–LED Irradiation

Chemistry – A European Journal, EarlyView.
This study presents a green and efficient photochemical protocol for the deprotection of ortho‐nitrobenzyl esters or ethers under mild conditions, using UVA‐LED irradiation in methanol. The broad applicability of the protocol was validated in the synthesis of a cytosolic phospholipase A2 inhibitor. ABSTRACT The removal of protecting groups in synthetic
Despoina Poikilidou, Christiana Mantzourani, George Kokotos, Christoforos G. Kokotos   +3 more
wiley   +1 more source

Sucrose Treatment Enhances the Electrotransfer of DNA by Activating Phospholipase A2

Pharmaceutics
Our previous study discovered that sucrose and other non-reducing sugars (e.g., trehalose and raffinose) could be used to improve the electrotransfer (ET) of molecular cargo, including DNA, mRNA, and ribonucleoprotein in various cell lines and primary ...
Chunxi Wang, Chun-Chi Chang, Jen-Tsan Chi, Fan Yuan   +3 more
doaj   +1 more source

A Tentative Mechanism of Solubilization of Neuropathy Target Esterase from Chicken Embryo Brain by Phospholipase A2

The Scientific World Journal, 2008
The neuropathy target esterase is a membrane-bound enzyme linked to organophosphate-induced distal neuropathy. Here we report a tentative mechanism of its solubilization from chicken embryo brains by using phospholipase A2.
Josef Seifert
doaj   +1 more source

Two unusual cases of PLA2G6-associated neurodegeneration from India

Annals of Indian Academy of Neurology, 2016
Phospholipase A2-associated neurodegeneration (PLAN) comprises of three disorders with overlapping presentations. The most common of these is classical or infantile-onset phospholipase A2-associated neurodegeneration, also known as infantile neuroaxonal ...
Shilpa D Kulkarni, Meenal Garg, Rafat Sayed, Varsha A Patil   +3 more
doaj   +1 more source