Results 51 to 60 of about 67,252 (282)

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Economic Benefit of Anti-PLA2R Antibody Testing in the Diagnosis of Membranous Nephropathy: A Single-Center Cost Analysis

Turkish Journal of Nephrology
Background: This study aimed to evaluate the financial impact of using anti-phospholipase A2 receptor antibody testing instead of kidney biopsy for diagnosing membranous nephropathy.
Asil Demirezen, Nuri Alperen Malkoç, Ömer Faruk Akçay, Saliha Yıldırım, Emre Yaşar, Sena Türkmen, Emre Yaşar, Sena Türkmen, Özlem Gülbahar, Betül Öğüt, İpek Işık Gönül, Galip Güz, Ülver Derici, Yasemin Erten, Kadriye Altok, Özant Helvacı   +15 more
doaj   +1 more source

Phospholipase A2 Receptor Antibody IgG4 Subclass Improves Sensitivity and Specificity in the Diagnosis of Idiopathic Membranous Nephropathy

Kidney & Blood Pressure Research, 2019
Aims: The aim of this study was to develop a new method for detecting anti-phospholipase A2 receptor-IgG4 to improve the sensitivity and specificity in the diagnosis of idiopathic membranous nephropathy (IMN).
Biao Huang, Yi Zhang, Liang Wang, Wenwei Xu, Jue Zhang, Qiuhua Zhang, Huiming Sheng, Zhigang Hu   +7 more
doaj   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

A Tentative Mechanism of Solubilization of Neuropathy Target Esterase from Chicken Embryo Brain by Phospholipase A2

The Scientific World Journal, 2008
The neuropathy target esterase is a membrane-bound enzyme linked to organophosphate-induced distal neuropathy. Here we report a tentative mechanism of its solubilization from chicken embryo brains by using phospholipase A2.
Josef Seifert
doaj   +1 more source

Two unusual cases of PLA2G6-associated neurodegeneration from India

Annals of Indian Academy of Neurology, 2016
Phospholipase A2-associated neurodegeneration (PLAN) comprises of three disorders with overlapping presentations. The most common of these is classical or infantile-onset phospholipase A2-associated neurodegeneration, also known as infantile neuroaxonal ...
Shilpa D Kulkarni, Meenal Garg, Rafat Sayed, Varsha A Patil   +3 more
doaj   +1 more source

Phospholipase A2 and Phospholipase B activities in fungi [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source.
Gerwald A, Köhler, Audrey, Brenot, Eric, Haas-Stapleton, Nina, Agabian, Rupal, Deva, Santosh, Nigam   +5 more
openaire   +2 more sources

Sucrose Treatment Enhances the Electrotransfer of DNA by Activating Phospholipase A2

Pharmaceutics
Our previous study discovered that sucrose and other non-reducing sugars (e.g., trehalose and raffinose) could be used to improve the electrotransfer (ET) of molecular cargo, including DNA, mRNA, and ribonucleoprotein in various cell lines and primary ...
Chunxi Wang, Chun-Chi Chang, Jen-Tsan Chi, Fan Yuan   +3 more
doaj   +1 more source

Differential determination of phospholipase A2 and PAF-acetylhydrolase in biological fluids using fluorescent substrates

Journal of Lipid Research, 1999
The purpose of the present study was the development and evaluation of a fluorimetric method for the screening and differential determination of phospholipase A2 and PAF-acetylhydrolase in bronchoalveolar lavage (BAL) fluid and serum.
Eirini I. Kitsiouli, George Nakos, Marilena E. Lekka   +2 more
doaj   +1 more source

Secreted phospholipase A2 revisited [PDF]

Journal of Biochemistry, 2011
Phospholipase A(2) (PLA(2)) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 enzymes that possess PLA(2) or related activity have been identified in mammals. About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular
Makoto, Murakami, Yoshitaka, Taketomi, Hiroyasu, Sato, Kei, Yamamoto   +3 more
openaire   +2 more sources