Results 31 to 40 of about 343,412 (268)

Synthesis of photoreactive phosphatidylethanolamine and its interaction with phospholipase A2.

Journal of Lipid Research, 1994
A photoreactive derivative of phosphatidylethanolamine, N-(4-azidobenzoyl)phosphatidylethanolamine (AB-PE), was synthesized by acylation of phosphatidylethanolamine with an N-hydroxysuccinimide ester of 4-azidobenzoic acid.
R Rajasekharan, J D Kemp
doaj   +1 more source

Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A)

Stem Cell Research, 2023
Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson’s disease (PD). We generated human induced pluripotent stem cell (iPSC)
Renjitha Gopurappilly, Thasneem Musthafa, Salil Sukumaran, Biju Viswanath, Gaiti Hasan   +4 more
doaj   +1 more source

Mammalian Phospholipase A2: Phospholipase A2 Receptor

Biological and Pharmaceutical Bulletin, 2004
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire   +3 more sources

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Gilfillan, Alasdair M., Kuehn, Hye Sun, Beaven, Michael A., Swindle, Emily J., Kim, Mi-Sun, Metcalfe, Dean D.   +5 more
core   +2 more sources

Clofazimine Induced Suicidal Death of Human Erythrocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis.
Arbace Officioso, Kousi Alzoubi, Caterina Manna, Florian Lang   +3 more
doaj   +1 more source

Adsorption of pancreatic (pro)phospholipase A2 to various physiological substrates.

Journal of Lipid Research, 1983
The adsorption of pancreatic phospholipase was studied in vitro in the presence of egg yolk lipoprotein emulsion, Intralipid emulsion, and milk fat globules.
G Nalbone, M Charbonnier-Augeire, H Lafont, R Grataroli, J L Vigne, D Lairon, C Chabert, J Leonardi, J C Hauton, R Verger   +9 more
doaj   +1 more source

Effect of phospholipids on the structure of Triatoma infestans lipophorin studied by fluorescence methods

Journal of Lipid Research, 1996
To study the role of phospholipids in the lipophorin structure, they were removed by phospholipase A2 treatment. Fluorescence lifetimes and accessibility to acrylamide quenching of different diphenylhexatrienyl derivatives, which were used as analogues ...
O J Rimoldi, H A Garda, R R Brenner
doaj   +1 more source

Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope. [PDF]

PLoS ONE, 2014
The Flaviviridae family includes several virus pathogens associated with human diseases worldwide. Within this family, Dengue virus is the most serious threat to public health, especially in tropical and sub-tropical regions of the world.
Vanessa Danielle Muller, Ricardo Oliveira Soares, Nilton Nascimento dos Santos, Amanda Cristina Trabuco, Adelia Cristina Cintra, Luiz Tadeu Figueiredo, Antonio Caliri, Suely Vilela Sampaio, Victor Hugo Aquino   +8 more
doaj   +1 more source

Regulatory Functions of Phospholipase A2

Critical Reviews in Immunology, 1997
Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF ...
Makoto, Murakami, Yoshihito, Nakatani, Gen-Ichi, Atsumi, Keizo, Inoue, Ichiro, Kudo   +4 more
openaire   +4 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source