Results 11 to 20 of about 315,246 (280)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]

, 2002
Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Quintel, Michael, Samman, Michael, Bertsch, Thomas, Aufenanger, Johannes, Fassbender, Klaus, Zimmer, Wilma, Michael Samman, Klaus Fassbender, Michael Quintel, Thomas Bertsch, Johannes Aufenanger, Wilma Zimmer   +11 more
core   +2 more sources

Predicting the mechanism of phospholipidosis [PDF]

, 2012
The mechanism of phospholipidosis is still not well understood. Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.
Mitchell, JBO, Glen, RC, Glen Robert C, Nigsch Florian, Mussa, HY, Robert Lowe, Florian Nigsch, Robert C Glen, Nigsch, F, Mussa, Hamse Y., Lowe, R, Glen, Robert C., Lowe Robert, John BO Mitchell, Mitchell John BO, Nigsch, Florian, Lowe, Robert, Mussa Hamse Y, Hamse Y Mussa, Mitchell, John B. O., Mitchell, John B. O.; id_orcid   +20 more
core   +5 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Viperidae snake venom phospholipase A2 . Biochemical targets for the action of protein in the human blood circulatory system. Part 1 (review of literature)

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya, L. V. Vasina, M. A. Galkin, Yu. V. Tarasova   +3 more
doaj   +1 more source

Secretory Phospholipase A2

Biological and Pharmaceutical Bulletin, 2004
Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA2 isozymes in mammals.
Murakami, Makoto, Kudo, Ichiro
openaire   +3 more sources

Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs).
Roberta Tancredi Francesco dos Santos, Marcelo Florencio Passos Silva, Rafael Marques Porto, Ivo Lebrun, Luís Roberto de Camargo Gonçalves, Isabel de Fátima Correia Batista, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla   +7 more
doaj   +1 more source

Group XV phospholipase A2, a lysosomal phospholipase A2 [PDF]

Progress in Lipid Research, 2011
A phospholipase A₂ was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. The phospholipase has the unique ability to transacylate short chain ceramides.
James A, Shayman, Robert, Kelly, Jessica, Kollmeyer, Yongqun, He, Akira, Abe   +4 more
openaire   +2 more sources

The Effects of Bee Venom on PLA2 and Calcium Concentration in Raw 264.7 Cells

Journal of Pharmacopuncture, 2003
Objectives : The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide, sodium nitroprusside and hydrogen peroxide induced expression phospholipase A2 and calcium concentration in RAW 264.7 cells, a murine macrophage ...
Jong-Il Yun, Hyun-Chul Jo, Sung-Yong Sim, Kee-Hyun Kim   +3 more
doaj   +1 more source

Dietary Fish Oil and Zinc Reduced Plasma Prostaglandin E2 Content by Inhibiting Phospholipase A2 Production in Broilers

The Journal of Poultry Science, 2014
Two-factor experiment was designed to examine from lipid metabolism, proinflammatory eicosanoids, and lipid peroxidation for investigating the effects of dietary oils and zinc levels of cardiovascular system of broilers.
Guanzhong Liu, Shengying An, Jianmin Yuan, Yuming Guo, Dan Liu, Hui Chen, Renlu Huang   +6 more
doaj   +1 more source