Results 241 to 250 of about 118,465 (262)
Some of the next articles are maybe not open access.
Stimulation of Phospholipases A2 by Transglutaminases
1990Among the enzymes catalyzing post-translational modifications of proteins, transglutaminases (TG; EC 2.3.2.13) have been extensively characterized from the enzymological point of view (1–4). Nevertheless, the physiological role(s) of these enzymes, particularly the intracellular TGs, are still poorly understood.
Simone Beninati +3 more
openaire +3 more sources
Phospholipase A2 activity in dystrophinopathies
Neuromuscular Disorders, 1995Phospholipase A2 activity in human muscle with or without dystrophin abnormality was studied. The results showed an increased phospholipase A2 activity in Duchenne muscular dystrophy (DMD) patients (1160 +/- 160, P < 0.01) compared to controls (< 200 U mg-1).
Eva Backman +4 more
openaire +3 more sources
Inhibition of phospholipase A2 by heparin
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990Phospholipase A2 (PLA2) is an important enzyme in the regulation of cell behavior. The hydrolysis of phosphatidylcholine in vitro catalyzed by porcine pancreatic PLA2 was inhibited by heparin. Other glycosaminoglycans inhibited PLA2 activity to a significantly lesser extent, with a pattern of inhibition: heparin much greater than chondroitin sulfate ...
Judith A.K. Harmony +3 more
openaire +2 more sources
Immunochemical relatedness between secretory phospholipase A2 and intracellular·phospholipase A2
Biochemical and Biophysical Research Communications, 1985The immunochemical relationship between rat pancreatic phospholipase A2 and rat splenic phospholipase A2 was examined with the use of anti-rat pancreatic phospholipase A2 antibody as a probe. The immunoelectrophoretic patterns showed that the antibody cross-reacted with the splenic enzyme.
Hiromasa Tojo +3 more
openaire +3 more sources
Phospholipase A2, an in vivo immunomodulator
Prostaglandins, Leukotrienes and Essential Fatty Acids, 1990Arachidonic acid (AA) can be released from membrane phospholipids by the action of phospholipase A2 (PLA2). There is evidence that unsaturated fatty acids, particularly AA, released from membrane phospholipids are required to activate the respiratory burst of macrophages.
S. Orbach-Arbouys +2 more
openaire +2 more sources
[Pancreatic phospholipase A2].
Nihon rinsho. Japanese journal of clinical medicine, 1996Pancreatic phospholipase A2 is one of the digestive enzymes in pancreatic juice. As there are other phospholipase activities in the serum, serum pancreatic phospholipase A2 is measured by immunoassay. A decrease in the serum level of this enzyme is significantly correlated with pancreatic dysfunction demonstrated by the secretin test.
openaire +4 more sources
Involvement of phospholipase A2 in neurodegeneration
Neurochemistry International, 1997Phospholipases A2 are a heterogeneous class of enzymes that hydrolyse fatty acids from the sn-2 2 position of membrane phospholipids. Prolonged stimulation of phospholipase A2 may damage membrane integrity, not only because of the loss of essential phospholipid from the lipid bilayer but also as a result of an uncontrollable Ca2+ influx.
Lloyd A. Horrocks +2 more
openaire +3 more sources
, 2008 Phospholipase A2 — Regulation and inhibition
Klinische Wochenschrift, 1989Phospholipase A2 (PLA2) has been implicated in the pathogenesis of different diseases. Thus, the pharmacological intervention of PLA2 activity by specific inhibitors is of great therapeutical value in ameliorating pathological conditions. Despite a great number of published data regarding PLA2 inhibitors none has reached clinical application.
openaire +3 more sources