Results 241 to 250 of about 67,252 (282)

Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2

Prostaglandins & Other Lipid Mediators, 2002
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor. PLA2R regulates a variety of biological responses elicited by specific types of secretory PLA2s (sPLA2s).
Kohji, Hanasaki, Hitoshi, Arita
openaire   +2 more sources

Inhibition of phospholipase A2 and phospholipase C by polyamines

Archives of Biochemistry and Biophysics, 1978
Abstract The polyamines spermine, spermidine, and putrescine inhibit the activity of phospholipase A2 (Naja naja) and phospholipase C (Clostridium welchii) on phospholipid vesicles and mitochondrial membranes as sources of substrate phospholipids. The inhibitory effect is highest for spermine and lowest for putrescine.
A M, Sechi, L, Cabrini, L, Landi, P, Pasquali, G, Lenaz   +4 more
openaire   +2 more sources

Serum phospholipase A2 in dengue

Journal of Infection, 1997
Group II phospholipase A2 is an enzyme involved in the pathologies of various inflammatory diseases, including infections. We measured the concentration of group II phospholipase A2 in sera of 49 patients suffering from dengue, virus serotype 3, during a recent epidemic in The Cook Islands.
T J, Nevalainen, W, Losacker
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Mechanisms of inhibition of phospholipase A2

Biochemical Pharmacology, 1980
Abstract Differential scanning calorimetry (d.s.c.) and assays of phospholipase A2 activity were used as tools to distinguish between drugs which interact with the phospholipids and those which interact directly with the enzyme. Cholesterol lowered the transition temperature (tc) and reduced the heat absorbed at transition and inhibited phospholipase
C, Vigo, G P, Lewis, P J, Piper
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Phospholipase A2, an in vivo immunomodulator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1990
Arachidonic acid (AA) can be released from membrane phospholipids by the action of phospholipase A2 (PLA2). There is evidence that unsaturated fatty acids, particularly AA, released from membrane phospholipids are required to activate the respiratory burst of macrophages.
A, Bravo Cuellar, F, Homo-Delarche, S, Orbach-Arbouys   +2 more
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Phospholipase A2 inhibitors in development

Expert Opinion on Investigational Drugs, 1997
To date, three isoforms of phospholipase A2 (PLA2) have been identified. Of these, the two Ca2+-dependent isoforms, secretory (sPLA2) and cytosolic phospholipase A2 (cPLA2), are targets for new anti-inflammatory drugs. The catalytic mechanisms and functions of the third isoform, Ca2+-independent cytosolic phospholipase A2 (iPLA2), are unknown at ...
U, Tibes, W G, Friebe
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Phospholipase A2

1997
Part 1 Structure, distribution and function of phospholipase A2: history, classification, structure and function of phospholipase A2 expression of group II phospholipase A2 in human tissues determinants of the antimicrobial action of 14-kD phospholipase A2 downregulation of cytokine-induced synthesis and secretion of group II phospholipase A2 control ...
openaire   +1 more source

Secretory phospholipases A2

Journal of Lipid Mediators and Cell Signalling, 1995
M, Murakami, I, Kudo, K, Inoue
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[Phospholipase A2].

Seikagaku. The Journal of Japanese Biochemical Society, 2011
Kei, Yamamoto, Makoto, Murakami
  +5 more sources

Phospholipase A2

RCSB Protein Data Bank, 2019
Markus Büchler, Waldemar Uhl, Timo J. Nevalainen   +2 more
openaire   +2 more sources