Results 71 to 80 of about 18,826,497 (287)

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Phospholipase C-β 2 interacts with mitogen-activated protein kinase kinase 3

, 2002
Phospholipase C (PLC)-β enzymes (isoenzymes β1–β4) are activated by G protein subunits, leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C.
Barr, A.J., Snyderman, R., Xu, J., Marjoram, R.J.   +3 more
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates

Angewandte Chemie, EarlyView.
An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho, Cindy Y. Jao, Zijun Xia, Brittany M. White‐Mathieu, Adrian Salic, Jeremy M. Baskin   +5 more
wiley   +2 more sources

Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants

Frontiers in Plant Science, 2019
Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues ...
Tomáš Takáč, Dominik Novák, Jozef Šamaj   +2 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Study of the influence of various physiologically active substances on changes in the lipid composition and phospholipase activity of damaged somatic nerves [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология
The changes in lipid composition and phospholipase activity in damaged somatic nerves were studied against the background of the action of potassium hyaluronate and insulin-like growth factor-1.
Revin, Viktor V., Parchaykina, Marina V., Chudaikina, Elena V., Revina, Elvira S., Molchanov, Ivan D., Simakova, Milena A., Zavarykina, Anastasia Vyacheslavovna, Grunyushkin, Igor P., Devyatkin, Arkadiy А.   +8 more
doaj   +1 more source