Results 71 to 80 of about 15,647,203 (259)
Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini
Journal of Lipid Research, 2002 Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés +11 more
doaj
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer [PDF]
arXiv, 2006 Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate at a given point in time. Here, we present a novel three-dimensional multiscale agent-based model to simulate this
arxiv
Mapping Complex Networks: Exploring Boolean Modeling of Signal Transduction Pathways [PDF]
arXiv, 2009 In this study, we explored the utility of a descriptive and predictive bionetwork model for phospholipase C-coupled calcium signaling pathways, built with non-kinetic experimental information. Boolean models generated from these data yield oscillatory activity patterns for both the endoplasmic reticulum resident inositol-1,4,5-trisphosphate receptor ...
arxiv
BMC Biology, 2014 Klebsiella pneumoniae strains are pathogenic to animals and humans, in which they are both a frequent cause of nosocomial infections and a re-emerging cause of severe community-acquired infections. K.
Leticia M. S. Lery +10 more
semanticscholar +1 more source
On optimality of designs with three distinct eigenvalues [PDF]
arXiv, 2012 Let $\D_{v,b,k}$ denote the family of all connected block designs with $v$ treatments and $b$ blocks of size $k$. Let $d\in\D_{v,b,k}$. The replication of a treatment is the number of times it appears in the blocks of $d$. The matrix $C(d)=R(d)-\frac{1}{k}N(d)N(d)^\top$ is called the information matrix of $d$ where $N(d)$ is the incidence matrix of $d$
arxiv
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners*
Journal of Biological Chemistry, 2004 Anandamide (N-arachidonoylethanolamine) is known to be an endogenous ligand of cannabinoid and vanilloid receptors. Its congeners (collectively referred to as N-acylethanolamines) also show a variety of biological activities.
Y. Okamoto +4 more
semanticscholar +1 more source
Journal of Lipid Research, 2001 Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar +5 more
doaj
Role of Phospholipase D in G-Protein Coupled Receptor Function
Membranes, 2014 Prolonged agonist exposure of many G-protein coupled receptors induces a rapid receptor phosphorylation and uncoupling from G-proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation.
Lars-Ove Brandenburg +2 more
doaj +1 more source
On the automorphism groups of algebraic bounded domains [PDF]
arXiv, 1994 Let $D$ be a bounded domain in $C^n$. By the theorem of H.~Cartan, the group $Aut(D)$ of all biholomorphic automorphisms of $D$ has a unique structure of a real Lie group such that the action $Aut(D)\times D\to D$ is real analytic. This structure is defined by the embedding $C_v\colon Aut(D)\hookrightarrow D\times Gl_n(C)$, $f\mapsto (f(v), f_{*v ...
arxiv
Journal of Cell Biology, 2013 The BBSome, a regulator of ciliary membrane protein composition, is required only for the export phase of a process that continuously cycles phospholipase D through cilia.
K. Lechtreck +6 more
semanticscholar +1 more source