Results 151 to 160 of about 23,252 (262)

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection. [PDF]

Mol Microbiol
Kilinç G, van den Biggelaar RHGA, Ottenhoff THM, Mei LH, Saris A.   +4 more
europepmc   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

<i>Rhodotorula</i> spp. in Laboratory and Veterinary Clinical Practice: Contamination or an Emerging Problem? [PDF]

Animals (Basel)
Wykrętowicz K, Czyżewska-Dors E, Dors A, Pomorska-Mól M, Augustyniak A, Łagowski D.   +5 more
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

A unified digital twin framework for predicting therapeutic response to central nervous system infections by pathogenic free-living amoebae. [PDF]

Parasitol Res
Siddiqui R, Maciver SK, Lloyd D, Khan NA.   +3 more
europepmc   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

<i>Trichophyton rubrum</i> Phenotypic Virulence Factors in Mexican Strains. [PDF]

Biology (Basel)
Conde-Cuevas E, Hernández-Castro R, Fuentes-Venado CE, Arenas R, Frías-De-León MG, Moreno-Coutiño G, Ocharan-Hernández ME, Farfan-Garcia ED, Pinto-Almazán R, Martínez-Herrera E.   +9 more
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation. [PDF]

Scientifica (Cairo)
Sofyantoro F, Kusuma WA, Wahyudi ST, Lumbanraja FR, Rahmawan H, Rustamaji HC, Kurniawan DW, Rastuti U, Putri WA, Wibowo WA, Priyono DS, Yudha DS, Raharjo S, Nuringtyas TR.   +13 more
europepmc   +1 more source