Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential
Phytotherapy Research, EarlyView.Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi +5 more
wiley +1 more source
Phospholipase PLA2G5-triggered hemolysis emerges as a contributor to sepsis lethality. [PDF]
J Clin InvestCavaillon JM.
europepmc +1 more source
Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
Identification and in-depth characterization of clinical isolates of <i>Peribacillus frigoritolerans</i>. [PDF]
Microbiol SpectrCalvigioni M +6 more
europepmc +1 more source
Small, EarlyView.This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li +3 more
wiley +1 more source
Endometritis and endometrial fibrosis are associated with alterations in mare endometrial proteome. [PDF]
BMC Vet ResLeal M +10 more
europepmc +1 more source
Chemical and Biological Determinants of PEG‐Lipid Shedding From Therapeutic Nanoparticles
Small, EarlyView.PEG‐lipids play a central role in governing lipid nanoparticle stability, targeting, and function. However, PEG‐lipids can “shed” from the nanoparticle surface in biological environments, with the extent and kinetics of shedding influenced by chemical and biological factors.
Ethan P. Cisneros +2 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Transcriptomic Dissection of <i>Bothrops moojeni</i> Venom Reveals Fraction-Specific Modulation of Host Cellular Pathways. [PDF]
Int J Mol SciD'Amélio F +4 more
europepmc +1 more source
Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights
Smart Molecules, EarlyView.Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan +5 more
wiley +1 more source