Results 131 to 140 of about 23,252 (262)

Homology Analysis of <i>Polistes dominula</i> and <i>Vespula</i> spp. Venoms: A Comparative In Vitro and In Silico Study. [PDF]

Toxins (Basel)
Morales M, Jordá Marín A, Cases B, Wallace L, Rojas DHF.   +4 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Snake Venom PLA₂ as Anticoagulant Agents: Role of Crotoxin, from <i>Crotalus durissus</i> Rattlesnake, in Hemostasis. [PDF]

Toxins (Basel)
Brasileiro-Martins LM, Marques GD, Maciel JB, Neiva M, Nascimento TP, Reyes DJE, Feitosa AJC, Angiole-Cavalcante S, Aquino PF, Sachett JAG, Monteiro WM, Sartim MA.   +11 more
europepmc   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

New Insights into the Bioenergetic and Immunomodulatory Properties of Phospholipases A₂ from <i>Bothrops diporus</i> Venom. [PDF]

Toxins (Basel)
Sasovsky DJ, Oliveira AK, Silva DT, Ojeda GA, Almarza C, Lomonte B, Fox JW, Urra FA, Bustillo S.   +8 more
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Draft Genome Sequence of Multidrug-Resistant <i>Acinetobacter baumannii</i> smu isolated from a Bloodstream Infection in Sikkim, India. [PDF]

J Genomics
Sharma R, Das R, Bhutia YR, Pradhan N, Bhattarai A.   +4 more
europepmc   +1 more source

Phospholipase C and phosphatidylinositol phospholipase C.

Clinical Chemistry, 1987
K, Hawrylak, R A, Stinson
openaire   +2 more sources

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source