Results 111 to 120 of about 28,776 (298)

Secretory Phospholipases A2 in Plants

open access: yesFrontiers in Plant Science, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
María Elisa Mariani   +4 more
doaj   +1 more source

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

open access: yesChemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui   +5 more
wiley   +1 more source

Recent Progress on Phospholipases: Different Sources, Assay Methods, Industrial Potential and Pathogenicity

open access: yes, 2011
Significant studies on phospholipases optimization, characterization, physiological role and industrial potential have been conducted worldwide. Some of them have been directed for biotechnological advances such as gene discovery and functional ...
Ramrakhiani, Lata   +3 more
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara   +20 more
wiley   +1 more source

Phospholipases A2: structure and function

open access: yes, 2005
Phospholipases A2 (PLA2) are an example of peripheral membrane proteins that must first bind to the phospholipid interface to allow phospholipid hydrolysis to occur.
Wilton, David C.
core   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Identification, isolation and purification of neurotoxic phospholipases A2 from Vipera russelli venom using polyclonal antibodies

open access: yes, 1992
All the neurotoxic phospholipases A2 present in whole Vipera russelli venom were precipitated selectively from other non-neurotoxic phospholipases A2 and non-phospholipases A2 fractions using antibodies (anti PL-V Ig) raised against one of the purified ...
Veerabasappa Gowda, T., Kasturi, S.
core  

Data_Sheet_1_Secretory Phospholipases A2 in Plants.pdf

open access: yes, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Gerardo Daniel Fidelio (6937166)   +1 more
core   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

open access: yesDrug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi   +13 more
wiley   +1 more source

Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations.

open access: yes, 2013
International audienceThe present review aims to systematically and critically analyze the current knowledge on phospholipases and their role in physiological and pathological mineralization undertaken by mineralization competent cells.
Bandorowicz-Pikula, Joanna   +13 more
core   +1 more source

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