Results 91 to 100 of about 43,311 (255)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Subcellular localization of the phospholipases A of rat heart: evidence for a cytosolic phospholipase A1.

Journal of Lipid Research, 1985
During myocardial ischemia increased levels of lysoglycerophospholipids have been reported which may be deleterious to myocardial function. Phospholipases are presumed to be important in the regulation of this process.
G Nalbone, K Y Hostetler
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Approaches to the study of mammalian cellular phospholipases.

Journal of Lipid Research, 1985
The purpose of this article is to present some problems encountered in the study of cellular phospholipases and some approaches used in answering these problems.
M Waite
doaj   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Molecular evolution of MAX effectors in the rice blast fungus Pyricularia oryzae [PDF]

, 2015
Fungal plant pathogens secrete proteins, termed “effectors”, that enable them to interact with their hosts and to influence the outcome of the interaction.
Charriat, F., Cros-Arteil, Sandrine, Fournier, Elisabeth, Gladieux, Pierre, Gracy, Jérôme, Kroj, Thomas, Ravel, Sébastien   +6 more
core  

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

A cAMP-binding ectoprotein in the yeast Saccharomyces cerevisiae [PDF]

, 1991
tides 10, 593 ...
Achstetter T., Baroni M. D., Behrens M. M., Biilow R., Bregman D. B., Brunton L. L., Cannon J. F., Caras I. W., Caras I. W., Carr S. A., Clegg C., Conzelmann A., Conzelmann A., Corbin J. D., Cross G. A. M., Dallner G., Davitz M. A., Davitz M. A., DeCamilli P., Doering T. L., Edelman A. M., Ferguson M. A. J., Ferguson M. A. J., Ferguson R., Fersht A., Flockart D. A., Gruber W., Hixson C. S., Ishihara M., Jaynes P. K., Johnson K. E., Kamps M. P., Kiibler D., Korc-Grodzicki B., Kunisawa R., Lang B., Lohmann S. M., Lohmann S. M., Low M. G., Low M. G., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Merino A., Mitts M. R., Mostov K. E., Muller G., Muller G., Muller G., Muller G„, Nairn A. C., Nigam S. K., Nigg E. A., Nigg E. A., Olson S., Pall G., Rhee T., Rodel G., Sakar D., Salomon Y., Smith M. E., Srere P. A., Stieger A., Takami N., Thorner J., Toda T., Trams E. G., Uno I., Vai M., Wen T. C., Wingender-Drissen R.   +72 more
core   +3 more sources