Results 91 to 100 of about 28,776 (298)

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

open access: yesAdvanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan   +14 more
wiley   +1 more source

Subcellular localization of the phospholipases A of rat heart: evidence for a cytosolic phospholipase A1.

open access: yesJournal of Lipid Research, 1985
During myocardial ischemia increased levels of lysoglycerophospholipids have been reported which may be deleterious to myocardial function. Phospholipases are presumed to be important in the regulation of this process.
G Nalbone, K Y Hostetler
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

open access: yesAdvanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang   +3 more
wiley   +1 more source

Approaches to the study of mammalian cellular phospholipases.

open access: yesJournal of Lipid Research, 1985
The purpose of this article is to present some problems encountered in the study of cellular phospholipases and some approaches used in answering these problems.
M Waite
doaj   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang   +8 more
wiley   +1 more source

Role of Phospholipases in Fungal Fitness, Pathogenicity and Drug Development- Lessons from Cryptococcus neoformans

open access: yesFrontiers in Microbiology, 2010
Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
doaj   +1 more source

Hydrolytic Action of Phospholipases on Bacterial Membranes

open access: yes, 1977
Substrate specificities of phospholipases C [EC 3.1.4.3] from Clostridium novyi, Clostridium per-fringens. Bacillus cereus, and Pseudomonas aureofaciens were studied under the same conditions.
Hiroh Ikezawa, Ryo Taguchi
core  

Studies of potentially inflammatory phospholipases A2 and the effects of chloroquine-like agents

open access: yes, 1981
Studies of potentially inflammatory phospholipases A2 and the effects of chloroquine-like ...
Kalwant S. Authi (7166309)
core   +5 more sources

Mammalian Phospholipase A2: Phospholipase A2 Receptor

open access: yesBiological and Pharmaceutical Bulletin, 2004
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire   +3 more sources

Les phospholipases, enzymes clés de la physiologie spermatique

open access: yes, 2012
Chez les mammifères, la physiologie du spermatozoïde dans les voies génitales femelles est complexe, et plusieurs étapes bien définies doivent être franchies pour que le spermatozoïde puisse féconder l’ovocyte.
Jessica Escoffier   +6 more
core   +1 more source

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