Results 51 to 60 of about 144,128 (376)

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Ahmmed, Albert, Albert, Albert, Albert, Albert, Albert, Albert, Anthony P. Albert, Boualleque, Clapham, Davenport, Davenport, Drummond, Fukami, Hamill, Hardie, Helliwell, Inoue, Ivey, Kawanabe, Kinlay, Kwon, Large, Lemonnier, Liu, Miwa, Nakanishi, Nilius, Otsuguro, Peppiatt-Wildman, Rohacs, Saleh, Saleh, Saleh, Schiffrin, Sohag N. Saleh, Sugawara, Sumner, Trebak, Tseng, Vanhaesebroeck, Voets, Wang, William A. Large   +44 more
core   +2 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones

Molecules, 2016
Some novel hydrazone derivatives 6a–o were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis.
Nahed N. E. El-Sayed, Ahmed M. Alafeefy, Mohammed A. Bakht, Vijay H. Masand, Ali Aldalbahi, Nan Chen, Chunhai Fan, Abir Ben Bacha   +7 more
doaj   +1 more source

Phospholipases: From Structure to Biological Function

Biomolecules, 2021
Phospholipases are enzymes that cleave ester bonds within phospholipids [...]
María A. Balboa, Jesús Balsinde
doaj   +1 more source

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources

Phospholipase C [PDF]

, 2019
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times
Colin A, Bill, Charlotte M, Vines
openaire   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]

, 2013
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB, Boyle, SH, Churchill, E, Delnomdedieu, M, Fiehn, O, Kaddurah-Daouk, R, Krishnan, RR, Pickering, E, Rush, AJ, Wang, Z, Wikoff, WR, Zhu, H   +11 more
core   +2 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source