Results 231 to 240 of about 25,150,915 (368)

Understanding the role of small-molecule therapeutics for snake envenoming. [PDF]

EBioMedicine
Silva A, Isbister G.
europepmc   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Enhancing the Efficacy of Melanoma Treatment: The In Vitro Chemosensitising Impact of <i>Vipera ammodytes</i> Venom on Human Melanoma Cell Lines. [PDF]

Toxins (Basel)
Paolino G, Di Nicola MR, Raggi C, Camerini S, Casella M, Pasquini L, Zanetti C, Russo V, Mercuri SR, Lugini L, Federici C.   +10 more
europepmc   +1 more source

PHOSPHOLIPASE A₂ ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS [PDF]

, 1978
Geoffrey J. Blackwell, R.J. Flower, Frans P. Nijkamp, John R. Vane   +3 more
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Biochemical characterization and activity profiling of recombinant phospholipase A2 from Hemiscorpius lepturus expressed in E. coli with in vivo antibody response. [PDF]

Sci Rep
Najafi M, Shahbazzadeh D, Yaghmaie P, Mirzahoseini H.   +3 more
europepmc   +1 more source

Action of pancreatic phospholipase A2 on phosphatidylcholine bilayers in different physical states [PDF]

, 1975
Jos A.F. Op den Kamp, M.Th. Kauerz, L.L.M. Van Deenen   +2 more
openalex   +1 more source

Contribution of individual phospholipase A₂ enzymes to the cleavage of oxidized phospholipids in human blood plasma. [PDF]

J Lipid Res
Jokesch P, Oskolkova O, Fedorova M, Gesslbauer B, Bochkov V.   +4 more
europepmc   +1 more source

Transcriptional response in larvae of the generalist fruit fly Anastrepha obliqua feeding on three different tropical host plants

Entomologia Experimentalis et Applicata, EarlyView.
We investigated the molecular basis of host switching by the phytophagous West Indian fruit fly (A. obliqua). Third‐instar larvae showed differential gene expression according to host plants: red mombin, mango, and carambola. The main gene categories differentially expressed were digestion, detoxification, and gene regulators.
Sandra M. Velasco‐Cuervo, César A. Lemos‐Lucumi, Maria R. Manzano, Stephen E. Strelkov, Nelson Toro‐Perea, Leonardo Galindo‐González   +5 more
wiley   +1 more source

High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis. [PDF]

J Transl Med
Wang X, Li S, Liu C, Zhao J, Ren G, Zhang F, Liu X, Cao S, Xu Y, Xia Z, Xia Z.   +10 more
europepmc   +1 more source