Results 291 to 300 of about 72,860 (341)

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Effects of phospholipase C inhibition on the regulation of membrane lipid metabolism in maize leaves. [PDF]

Front Plant Sci
Wei Y, Cai Z, Che Z, Guo X, Ge S, Che X, Deng J, Zhang H, He L, Xu J.   +9 more
europepmc   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption. [PDF]

Nat Commun
Kong J, Wu W, Ke S, Zhou Z, Xia S, Chen J, Zhu R, Hou Y, Makanyire T, Shan X, Zhuo Z, Li K, Shen H, Yang P, Huang P, Liu J, Li J, Sun X, Dong J, Sun H, Chen M, Lu M, Li Z, Xiao Y.   +23 more
europepmc   +1 more source

Wounding and Phospholipase C Inhibition: Evaluation of the Alkaloid Profiling in Opium Poppy. [PDF]

Plants (Basel)
Hans B, Balažová E, Dokupilová S, Mikuš P, Balažová A, Kubíková R, Obložinský M.   +6 more
europepmc   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

Metabolic pathways of eicosanoids-derivatives of arachidonic acid and their significance in skin. [PDF]

Cell Mol Biol Lett
Biernacki M, Skrzydlewska E.
europepmc   +1 more source

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source

Animal Venoms as Potential Antitumor Agents Against Leukemia and Lymphoma. [PDF]

Cancers (Basel)
Malachias-Pires GM, Filardi ETM, Romanazzi M, Lopes-de-Oliveira J, Santos ICD, Melo-Dos-Santos G, Rossi AB, Procópio Machado M, Silva TAD, Pucca MB.   +9 more
europepmc   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, EarlyView.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source