Results 331 to 340 of about 22,290,738 (402)

Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption. [PDF]

Nat Commun
Kong J, Wu W, Ke S, Zhou Z, Xia S, Chen J, Zhu R, Hou Y, Makanyire T, Shan X, Zhuo Z, Li K, Shen H, Yang P, Huang P, Liu J, Li J, Sun X, Dong J, Sun H, Chen M, Lu M, Li Z, Xiao Y.   +23 more
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Phospholipase A2

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the ...
Bruno L, Diaz, Jonathan P, Arm
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Phospholipase A2 inhibitors

Current Opinion in Lipidology, 2009
As the role of lipids and inflammation in the genesis and progression of the atherosclerosis disease is unquestionable, novel treatment modalities that target both aspects are currently under investigation.For a long time atherosclerosis was regarded as a lipid-driven disease, but now it is evident that it also involves the simultaneous and combined ...
Garcia Garcia, Hector, Serruys, PWJC (Patrick)   +1 more
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Venom phospholipase A: A review

Toxicon, 1965
TIB3 cENERic term phospholipase designates a class of enzymes which specifically hydrolyze phospholipids. Four types of phospholipases are known-phospholipase A, B, C, D ; they are individually characterized by a specific site ofaction on the phospholipid molecule.
E, CONDREA, A, DEVRIES
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Phospholipases of marine invertebrates—I. distribution of phospholipase a

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1972
Abstract 1. 1. The activities of phospholipases A, C and D were determined in the extracts of forty-six species from the main systematic groups of marine invertebrates with phosphatidyl choline, phosphatidyl ethanolamine and sphingomyelin as substrates. 2. 2. The majority of animals contained phospholipases A. 3. 3.
V E, Vaskovsky, Z S, Suppes
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Phospholipase A2—a structural review

Toxicon, 1996
Phospholipases A2 (PLA2) are widely distributed in nature and are well characterized proteins with respect to their catalytic and pharmacological activities. A wealth of structural information has recently become available both from X-ray diffraction and NMR studies, and although a detailed model of the catalytic mechanism of PLA2 has been proposed ...
Arni, R. K., Ward, R. J.
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Phospholipase C- 1: A Phospholipase and Guanine Nucleotide Exchange Factor

Molecular Interventions, 2002
Although phospholipase C-gamma (PLC-gamma) participates in cellular mitogenesis, evidence indicates that the catalytic activity of PLC-gamma (to hydrolyze certain phosphoinositides) is nonessential to the process. So how is it that PLC-gamma is necessary but its lipase activity is not?
Zhixiang, Wang, Michael F, Moran
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Group XV phospholipase A₂, a lysosomal phospholipase A₂.

Progress in lipid research, 2011
A phospholipase A₂ was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. The phospholipase has the unique ability to transacylate short chain ceramides.
James A, Shayman, Robert, Kelly, Jessica, Kollmeyer, Yongqun, He, Akira, Abe   +4 more
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Phospholipase A2 isoforms: a perspective

Cellular Signalling, 2003
Several new PLA(2)s have been identified based on their nucleotide gene sequences. They were classified mainly into three groups: cytosolic PLA(2) (cPLA(2)), secretary PLA(2) (sPLA(2)), and intracellular PLA(2) (iPLA(2)). They differ from each other in terms of substrate specificity, Ca(2+) requirement and lipid modification.
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Assay of Phospholipase A Activity

2013
Phospholipases of the A type constitute a large family of esterases that catalyze the hydrolysis of the fatty acid ester bonds in phospholipids and thus generate lysophospholipids and fatty acids. Both products or their metabolites are important signal molecules in the cellular adaptation to stress, developmental processes and several diseases in ...
Michael, Heinze, Werner, Roos
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