Results 261 to 270 of about 30,818 (310)
Some of the next articles are maybe not open access.
Prostaglandins & Other Lipid Mediators, 2002
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators.
Ichiro Kudo, Makoto Murakami
openaire +3 more sources
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators.
Ichiro Kudo, Makoto Murakami
openaire +3 more sources
Current Opinion in Lipidology, 2009
As the role of lipids and inflammation in the genesis and progression of the atherosclerosis disease is unquestionable, novel treatment modalities that target both aspects are currently under investigation.For a long time atherosclerosis was regarded as a lipid-driven disease, but now it is evident that it also involves the simultaneous and combined ...
Patrick W. Serruys +1 more
openaire +2 more sources
As the role of lipids and inflammation in the genesis and progression of the atherosclerosis disease is unquestionable, novel treatment modalities that target both aspects are currently under investigation.For a long time atherosclerosis was regarded as a lipid-driven disease, but now it is evident that it also involves the simultaneous and combined ...
Patrick W. Serruys +1 more
openaire +2 more sources
Regulatory Functions of Phospholipase A2
Critical Reviews in Immunology, 1997Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF ...
Keizo Inoue +4 more
openaire +3 more sources
Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2
Prostaglandins & Other Lipid Mediators, 2002The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor. PLA2R regulates a variety of biological responses elicited by specific types of secretory PLA2s (sPLA2s).
Hitoshi Arita, Kohji Hanasaki
openaire +2 more sources
Lipoprotein-Associated Phospholipase A2 [PDF]
Clinics in Laboratory Medicine, 2006 Lipoprotein-associated phospholipase A2 (LP-PLA2) is an emerging inflammatory marker that is used to assess the risk for cardiovascular disease (CVD) and associated events. Several epidemiologic studies have demonstrated an independent association between plasma Lp-PLA2 concentration and risk for cardiovascular events.
Daniel M. Hoefner, Joseph P. McConnell
openaire +2 more sources
Extracellular Phospholipase A2
1992Various lipids have been implicated in signal transduction and as precursors of lipid mediators, among them arachidonic acid (Dennis et al., 1991). Production of the prostaglandins, thromboxanes, and prostacyclins via the cyclooxygenase pathway, as well as the production of the leukotrienes and lipoxins via the lipoxygenase pathway, all depend on the ...
Raymond A. Deems +2 more
openaire +3 more sources
1991
Publisher Summary This chapter describes the assay method, purification procedures, and properties of the spleen phospholipases A 2 enzymes. As an optimal molar ratio depends on the detergent-phospholipid combination, the ratio is determined for each set of detergent and phospholipid.
Takashi Ono +2 more
openaire +3 more sources
Publisher Summary This chapter describes the assay method, purification procedures, and properties of the spleen phospholipases A 2 enzymes. As an optimal molar ratio depends on the detergent-phospholipid combination, the ratio is determined for each set of detergent and phospholipid.
Takashi Ono +2 more
openaire +3 more sources
Polarographic assay for phospholipase A2
Analytical Biochemistry, 1980Abstract A rapid, specific, and quantitative assay for phospholipase A2 from Naja naja venom has been devised, in which phospholipid hydrolysis is measured as soybean lipoxidase-catalyzed oxygen incorporation into the ensuing unsaturated fatty acids. Under conditions where phospholipid was limiting, a linear relationship developed between the extent ...
Robert W. Egan, Paul H. Gale
openaire +3 more sources
Mechanisms of inhibition of phospholipase A2
Biochemical Pharmacology, 1980Abstract Differential scanning calorimetry (d.s.c.) and assays of phospholipase A2 activity were used as tools to distinguish between drugs which interact with the phospholipids and those which interact directly with the enzyme. Cholesterol lowered the transition temperature (tc) and reduced the heat absorbed at transition and inhibited phospholipase
C. Vigo, G.P. Lewis, Priscilla J. Piper
openaire +3 more sources
Phospholipase A2 in experimental hypertension
American Journal of Physiology-Legacy Content, 1975An assay method has been developed to measure phospholipase A2 (PLA2) in ratserum and to study the possible role of this enzyme in experimental hypertension. Experiments with rat serum following 48 h of bilateral nephrectomy indicated a decrease inPLA2 activity, suggesting that kidneys might be playing an important role in regulating serum PLA2 ...
FM Bumpus +4 more
openaire +3 more sources