Cloning, characterization, and expression analysis of goat (Capra hircus) phospholipid hydroperoxide glutathione peroxidase (PHGPx) [PDF]
International Journal of Biological Sciences, 2010 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), as a ubiquitous antioxidant enzyme in the glutathione peroxidases (GPx) family, plays multiple roles in organisms. However, there is very little information on PHGPx in goats (Capra hircus).
Li-guang SHI, Wen-juan XUN, Wen-bin YUE, Chun-xiang ZHANG, You-she REN, Qian WANG, Xiao-ying WU, Lei SHI, Ru-jie YANG, Fu-lin LEI
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Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness [PDF]
Redox Biology, 2023 Our previous studies support a key role for mitochondrial lipid hydroperoxides as important contributors to denervation-related muscle atrophy, including muscle atrophy associated with aging.
Agnieszka Czyżowska +7 more
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Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane [PDF]
Molecules, 2015 A series of fatty acid conjugates of trans-3,4-dihydroxy-1-selenolane (DHS) were synthesized by reacting DHS with appropriate acid chlorides. The obtained monoesters were evaluated for their antioxidant capacities by the lipid peroxidation assay using a
Michio Iwaoka +5 more
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Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells [PDF]
Frontiers in Physiology, 2015 Docosahexaenoic acid (DHA, 22:6n-3) is a unique polyunsaturated fatty acid particularly abundant in nerve cell membrane phospholipids. DHA is a pleiotropic molecule that, not only modulates the physicochemical properties and architecture of neuronal ...
Veronica eCasañas-Sanchez +4 more
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Structure and Functions of Phospholipid Hydroperoxide Glutathione Peroxidase
Journal of Japan Oil Chemists' Society, 1999 Phospholipid hydroperoxide glutathione peroxidase is the only known intracellular antioxidant enzyme directly capable of reduing peroxidized phospholipids and cholesterol in membranes. PHGPx is a member of the selenoprotein family that contain the unique amino acid, selenocysteine, the active site for peroxidase activity.
Hirotaka Imai, Yasuhito Nakagawa
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Ferroptosis: The Initiation Process of Lipid Peroxidation in Muscle Food [PDF]
AntioxidantsAnimal slaughtering causes the cessation of oxygen delivery and that of nutrients such as cystine, glucose and others to muscle cells. In muscle cells, the changes in oxygen level and pH cause mitochondria, the endoplasmic reticulum, xanthine oxidase and
Joseph Kanner, Adi Shpaizer, Oren Tirosh
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Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase [PDF]
Journal of Biological Chemistry, 1999 This study investigated phospholipid hydroperoxides as substrates for non-selenium GSH peroxidase (NSGPx), an enzyme also called 1-Cys peroxiredoxin. Recombinant human NSGPx expressed in Escherichia coli from a human cDNA clone (HA0683) showed GSH peroxidase activity with sn-2-linolenoyl- or sn-2-arachidonoyl-phosphatidylcholine hydroperoxides as ...
Aron B. Fisher +4 more
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Italian Journal of Animal Science, 2014 Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein, which protects biomembranes from oxidative damages, and it also accounts for almost the entire selenium content of mammalian testis.
Francesco Parillo +4 more
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Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. [PDF]
Acta Crystallogr F Struct Biol Commun, 2016 Janowski R, Scanu S, Niessing D, Madl T.
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The Role of Phospholipid Hydroperoxide Glutathione Peroxidase Isoforms in Murine Embryogenesis [PDF]
Journal of Biological Chemistry, 2006 Phospholipid hydroperoxide glutathione peroxidase (GPx4) is a selenocysteine-containing enzyme, and three different isoforms (cytosolic, mitochondrial, and nuclear) originate from the GPx4 gene. Homozygous GPx4-deficient mice die in utero at midgestation, since they fail to initiate gastrulation and do not develop embryonic cavities. To investigate the
Astrid Borchert +5 more
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