Results 61 to 70 of about 6,180 (194)

Potential Anti‐Aging Effects of a Dietary Supplement From the Algal‐Derived Omega‐3 DHA in Aged SAMP 8 Mice

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Algal‐derived Omega‐3 DHA supplementation exerts significant anti‐aging and neuroprotective effects in SAMP8 mice. Algal Omega‐3 DHA effectively mitigates age‐related cognitive decline, enhances antioxidant defenses, and extends lifespan. Algal‐derived Omega‐3 DHA supplementation enhances cognitive function, attenuates oxidative stress, and reduces ...
Ming‐Yu Chou, I‐Hung Lin, Chia‐Jung Chen, Ting‐Jian Guo, Che‐An Lin, Dao‐Na Yang, Po‐Hsien Li, Yu‐Chen Li, Mei‐Due Yang, Chieh‐Chang Tien, Ruei‐Ze Lin, Ching‐Hsin Chi, Shih‐Yi Wang, Ming‐Fu Wang   +13 more
wiley   +1 more source

Little effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia

BMC Urology, 2006
Background Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency.
Casares Amelia, Diaz-Sanchez Matias, Puche Juan, Garcia-Fernandez Maria, Castilla-Cortázar Inma, Diez-Caballero Fernando, Aliaga-Montilla M Aurelia, Rodriguez-Borrajo Coronación, Gonzalez-Barón Salvador   +8 more
doaj   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

An eQTL analysis of partial resistance to Puccinia hordei in barley.

PLoS ONE, 2010
BackgroundGenetic resistance to barley leaf rust caused by Puccinia hordei involves both R genes and quantitative trait loci. The R genes provide higher but less durable resistance than the quantitative trait loci. Consequently, exploring quantitative or
Xinwei Chen, Christine A Hackett, Rients E Niks, Peter E Hedley, Clare Booth, Arnis Druka, Thierry C Marcel, Anton Vels, Micha Bayer, Iain Milne, Iain Milne, Jenny Morris, Luke Ramsay, David Marshall, Linda Cardle, Robbie Waugh   +15 more
doaj   +1 more source

ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure

Particle and Fibre Toxicology, 2019
Background Nano-titanium dioxide (nano-TiO2) is amongst the most widely utilized engineered nanomaterials (ENMs). However, little is known regarding the consequences maternal ENM inhalation exposure has on growing progeny during gestation. ENM inhalation
Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, William T. Goldsmith, Andrya J. Durr, Garrett K. Fink, Timothy R. Nurkiewicz, John M. Hollander   +7 more
doaj   +1 more source

Long non-coding RNA H19 regulates Bcl-2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion. [PDF]

Exp Ther Med, 2021
Bai RX, Tang ZY.
europepmc   +1 more source

Oxidative stress leads to the formation of esterified erythro- and threo-dihydroxy-fatty acids in HepG2 cells

Redox Biology
Oxidative stress plays a central role in pathophysiology. To assess oxidative stress, sensitive methods are required to monitor the cellular damage caused by reactive oxygen species.
Lilli Scholz, Luca M. Wende, Michel A. Chromik, Nadja Kampschulte, Nils Helge Schebb   +4 more
doaj   +1 more source

Targeting ferroptosis for improved radiotherapy outcomes in HPV‐negative head and neck squamous cell carcinoma

Molecular Oncology
To enhance the efficacy of radiotherapy (RT) in human papillomavirus (HPV)‐negative head and neck squamous cell carcinoma (HNSCC), we explored targeting ferroptosis, a regulated cell death process.
Joo Kyung Noh, Min Kyeong Lee, Yeonseo Lee, Minji Bae, Soonki Min, Moonkyoo Kong, Jung Woo Lee, Su Il Kim, Young Chan Lee, Seong‐Gyu Ko, Seon Rang Woo, Young‐Gyu Eun   +11 more
doaj   +1 more source

Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer

Molecular Oncology
Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK‐TKIs) via emergence of a subpopulation of drug‐tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations.
Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura   +8 more
doaj   +1 more source