Results 101 to 110 of about 565,738 (381)

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes

Journal of Lipid Research, 2011
15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose, Brock T. Thuen, Mikhail Y. Golovko   +2 more
doaj  

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution

Pharmaceutics, 2020
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo, Jieun An, Changhee Park, Dohyun Kim, Jaehwi Lee   +4 more
doaj   +1 more source

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]

, 2005
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Bucciantini, Darkes, Duff, Ellis, Gilchrist, Harroun, Heller, Janson, Janson, Jeremy P. Bradshaw, Kelly, Kia Balali-Mood, Koebnik, Li, McIntosh, Mirzabekov, Richard H. Ashley, Rodrigues, Rodrigues, Stipani, Tenidis, Thomas Hauß, Tristram-Nagle, Walsh, Westermark, Wiener, Wigley, Wimley   +28 more
core   +1 more source

Structure of the Chemokine Receptor CXCR1 in Phospholipid Bilayers

Nature, 2012
CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth. IL-8, released in response to inflammatory stimuli, binds
Sang Ho Park, B. Das, Fabio Casagrande, Ye Tian, Henry J. Nothnagel, Mignon Chu, Hans Kiefer, Klaus Maier, A. De Angelis, F. Marassi, S. Opella   +10 more
semanticscholar   +1 more source

Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Semiconducting polymer nanoparticles (SPNs) exhibit many advantageous optical and biological properties. Multimodal SPN‐based contrast agents that integrate several imaging modalities yield a wealth of information through the use of different imaging mechanisms.
Faysal A. Farah, Yu Qin, Mark A. Green, James D. E. T. Wilton‐Ely   +3 more
wiley   +1 more source

Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria[S]

Journal of Lipid Research, 2011
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA). In this study, we show enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5.
Sneha S. Prasad, Abhimanyu Garg, Anil K. Agarwal   +2 more
doaj  

Advanced Oral Delivery Systems for Nutraceuticals

Advanced Healthcare Materials, EarlyView.
Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang, Linzixuan Zhang, Zhiling Zheng, Robert Langer, Ana Jaklenec   +4 more
wiley   +1 more source

Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

Journal of Lipid Research, 2002
Plaque disruption with superimposed thrombosis is considered to be responsible for precipitating acute coronary syndrome. We identified sn-1-alkyl- and sn-1-acyl-type glycerophosphocholine (GroPCho) core aldehydes from human atheromas and demonstrated ...
Hiroshi Kamido, Hiroyuki Eguchi, Hisao Ikeda, Tsutomu Imaizumi, Kazunari Yamana, Karsten Hartvigsen, Amir Ravandi, Arnis Kuksis   +7 more
doaj  

Biomolecule surface patterning may enhance membrane association

, 2012
Under dehydration conditions, amphipathic Late Embryogenesis Abundant (LEA) proteins fold spontaneously from a random conformation into alpha-helical structures and this transition is promoted by the presence of membranes.
Browne J., Garay-Arroyo A., Gkeka P., Goyal K., Illya G., Nigel K. H. Slater, Panchal R. G., Pogodin S., Pogodin S., Pogodin S., Pogodin S., Popova A. V., Sergey Pogodin, Tolleter D., Tunnacliffe A., Vladimir A. Baulin, Wise M. J., Yang L.   +17 more
core   +1 more source