Results 141 to 150 of about 209,802 (322)

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids

Journal of Lipid Research, 2004
To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Su Duy Nguyen, Dai-Eun Sok
doaj  

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of the Dezhou donkey, encompassing 20 tissues and 275 050 cells, is constructed. Through cross‐species and cross‐tissue analyses, distinct transcriptional patterns in donkey sebocytes are identified.
Yu Tian, Shuqin Liu, Hongtao Shi, Jianjun Li, Xinglong Wan, Yujiang Sun, Huayun Li, Ning Cao, Zhixi Feng, Teng Zhang, Junjie Wang, Wei Shen   +11 more
wiley   +1 more source

Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

Journal of Lipid Research, 1999
Because of the paucity of data on phospholipid transfer protein (PLTP) activity and lipoprotein phospholipid in mouse strains, plasma PLTP activity (PLTA), plasma phospholipid and cholesterol, HDL phospholipid and cholesterol, and HDL size distribution ...
John J. Albers, Wendy Pitman, Gertrud Wolfbauer, Marian C. Cheung, Hal Kennedy, An-Yue Tu, Santica M. Marcovina, Beverly Paigen   +7 more
doaj  

Phospholipide [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras

Journal of Lipid Research, 2006
The triglyceride (TG) lipase gene subfamily, consisting of LPL, HL, and endothelial lipase (EL), plays a central role in plasma lipoprotein metabolism. Compared with LPL and HL, EL is relatively more active as a phospholipase than as a TG lipase.
Nathalie Griffon, Elaine C. Budreck, Christopher J. Long, Uli C. Broedl, Dawn H.L. Marchadier, Jane M. Glick, Daniel J. Rader   +6 more
doaj  

THE IN VITRO FORMATION OF PHOSPHOLIPID BY BRAIN AND NERVE WITH RADIOACTIVE PHOSPHORUS AS INDICATOR

, 1942
B.A. Fries, Helga Schachner, I.L. Chaikoff   +2 more
openalex   +1 more source

Phospholipid metabolism in nervous tissue. 1. A reconsideration of brain and peripheral nerve phospholipid metabolism in vivo [PDF]

, 1959
Alan Davison, John Dobbing
openalex   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source