Results 71 to 80 of about 1,603 (150)

Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems

ChemSystemsChem, Volume 7, Issue 6, November 2025.
This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis, Joana Calvário, Inês Chibeles, Mohit Kumar, Ana S. Pina   +4 more
wiley   +1 more source

Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
PGN strains are generated by the deletion of virulence factor genes. The metabolic pathways and regulatory frameworks that lead to high‐efficiency production of rhamnolipids in P. aeruginosa are preserved in these strains. Therefore, PGN strains are promising bio‐safe cell factories for the industrial production of rhamnolipids.
Parvathy V. Das, Meagan E. Valentine, Timothy E. Long, Hongwei D. Yu   +3 more
wiley   +1 more source

HepG2 PMM2-CDG knockout model: A versatile platform for variant and therapeutic evaluation [PDF]

Phosphomannomutase 2 deficiency (PMM2-CDG), the most frequent congenital disorder of glycosylation, is an autosomal recessive disease caused by biallelic pathogenic variants in the PMM2 gene. There is no cure for this multisystemic syndrome.
Briso-Montiano Pastrana, Alvaro, Gallego Martínez, Diana, Gámez Abascal, María Alejandra, Martín Martínez, Arturo, Pérez González, María Belén, Ruiz Montes, Vera, Segovia Falquina, Cristina, Soriano Sexto, Alejandro, Vilas Lagoa, Alicia   +8 more
core   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Exploring ligand interactions with human phosphomannomutases using recombinant bacterial thermal shift assay and biochemical validation [PDF]

PMM2-CDG, a disease caused by mutations in phosphomannomutase-2, is the most common congenital disorder of glycosylation. Yet, it still lacks a cure. Targeting phosphomannomutase-2 with pharmacological chaperones or inhibiting the phosphatase activity of
Andreotti, Giuseppina, Cubellis, Maria Vittoria, Guerriero, Simone, Mele, Bruno Hay, Monticelli, Maria, Wright, Demi Marie   +5 more
core   +1 more source

D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles

Exploration, Volume 5, Issue 5, October 2025.
In this study, Zhang and colleagues show that drinking‐water supplementation of D‐mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression.
Sha Zhang, Kai Zhang, Chen‐Xi Zheng, Ying‐Feng Gao, Guo‐Rong Deng, Xu Zhang, Yuan Yuan, Ting Jia, Si‐Yuan Tang, Guang‐Xiang He, Zhen Gong, Na Zhao, Bo Ma, Hua Tian, Hong Zhang, Zhe Li, Yong‐Chang Di‐Wu, Yi‐Han Liu, Liang Kong, Jing Ma, Yan Jin, Bing‐Dong Sui   +21 more
wiley   +1 more source

Comparative genomics of Bradyrhizobium japonicum CPAC 15 and Bradyrhizobium diazoefficiens CPAC 7: elite model strains for understanding symbiotic performance with soybean. [PDF]

, 2017
The soybean-Bradyrhizobium symbiosis can be highly efficient in fixing nitrogen, but few genomic sequences of elite inoculant strains are available. Here we contribute with information on the genomes of two commercial strains that are broadly applied to ...
ALMEIDA, L. G. P., BARCELLOS, F. G., BATISTA, J. S. S., HUNGRIA, M., MARTÍNEZ-ROMERO, E., NAKATANI, A. S., ORMEÑO-ORRILLO, E., RODRIGUES, E. P., SIQUEIRA, A. F., SOUZA, R. C., VASCONCELOS, A. T. R.   +10 more
core   +1 more source

Genomic Characterization of Pan‐Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Klebsiella pneumoniae isolate KPNW showed resistance to all clinically relevant antibiotics. Upon whole genome sequencing and characterization, we detected a large number of antimicrobial resistance genes, resistance‐associated point mutations, virulence determinants, heavy metal resistance genes, and mobile genetic elements in errorits genome ...
Md. Wahid Murad, G. M. Shah Poran, Kalpana Baidya, Nazmul Ahsan   +3 more
wiley   +1 more source

Insuficiência ovárica prematura : análise da associação a outras falências endócrinas [PDF]

, 2011
Trabalho final de mestrado integrado em Medicina àrea científica de Ginecologia, apresentado à Faculdade de Medicina da Universidade de CoimbraA Insuficiência Ovárica Prematura caracteriza-se pela existência de uma disfunção primária do ovário que impede
Nunes, Ana Filipa Coutinho
core  

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches

Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.
ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto, Gabriel Rodrigues Coutinho Pereira, Isadora de Salles Arêas, Júlia Mendes Fortes, Alessandra da Silva Domingos, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Barbara de Azevedo Abrahim‐Vieira   +8 more
wiley   +1 more source