Results 141 to 150 of about 54,764 (213)

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Development of Tunable Materials From Well‐Defined Alendronic Acid Functionalized Polyacrylamide: An Opportunity for Actinide Decontamination

Journal of Polymer Science, Volume 64, Issue 6, Page 1431-1443, 15 March 2026.
Alendronate‐based copolymers for Nd and Ce recovery. ABSTRACT Bisphosphonic acid groups are emerging as promising functionalities for actinide decontamination, due to their high density of chelating sites. However, the chemistry of bisphosphonate (in particular alendronate) materials remains complex and underexplored.
Vincent Darcos, Loona Ferrie, Carlos Arrambide, Gabriele Vecchio, Nicolas Dacheux, Stephane Pellet‐Rostaing, Benedicte Prelot, Sophie Monge   +7 more
wiley   +1 more source

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
Negativ geladene Aryl‐Ethynyl‐Phosphonamid‐ und Phosphonsäuren werden als reaktionsarme Elektrophile für peptidbasierte Aktivitätssonden eingeführt, die eine selektive, zielspezifische Profilierung von Protein‐Tyrosin‐Phosphatasen ermöglichen. Die Sonden zeigen keine Off‐Target‐Cystein‐Reaktivität und binden in der globalen Proteomanalyse nur an die ...
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Fully protected pyrophosphates <i>via</i> phosphorobromidates for the synthesis of biopolymers. [PDF]

Chem Sci
Wijngaarden S, van der Heijden FLAM, Rijpkema KJ, van Puffelen B, Meeuwenoord NJ, Ramcharan D, van der Marel GA, Codée JDC, Overkleeft HS, Filippov DV.   +9 more
europepmc   +1 more source

One‐Pot Transition‐Metal‐Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
One‐pot transition‐metal‐free methods for the synthesis of all three bonds of the alkyne's triple bond are reviewed. After analysis of several named reactions and discussion of improvements, recent advances in the synthesis of alkynes are discussed. Each section contains a proposed reaction mechanism and analysis of the strengths and weaknesses of the ...
Eugene Kim, Yu Wu, Judith N. Currano, Jianyou Mao, Patrick J. Walsh   +4 more
wiley   +1 more source

Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates [PDF]

, 2008
Giessmann, Dirk, Haemers, Timothy, Hillaert, Ulrik, Jomaa, Hassan, Link, Andreas, Ortmann, Regina, Schlitzer, Martin, Van Calenbergh, Serge, Verbrugghen, Thomas, Wiesner, Jochen   +9 more
core   +1 more source

Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent. [PDF]

Nat Commun
Cai D, Huang L, Wang Z, Liu S, Xiao X, Zhao B.   +5 more
europepmc   +1 more source

Expanding the actinomycetes landscape for phosphonate natural products through genome mining. [PDF]

RSC Chem Biol
Zimmermann A, Xia SN, Moschny J, Gomez-Escribano JP, Boldt J, Nübel U, Nouioui I, Krause J, Irle MK, Metcalf WW, Hughes CC, Mast Y.   +11 more
europepmc   +1 more source

Bifunctional glycolipids targeting TLR4·MD-2 and short pentraxins. [PDF]

RSC Chem Biol
Zucchetta D, Nuschy L, Gumpelmair S, Steinberger P, Wilson I, Heine H, Zamyatina A.   +6 more
europepmc   +1 more source