Results 101 to 110 of about 18,289 (229)

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li, Hao Zhang, Lingtong Sun, Yingfeng Su, Yang Xu, Jian Huang, Jingchao Wen, Jinjin Zhu, Jianjun Ma, Wenbin Xu   +9 more
wiley   +1 more source

The structure and mode of action of the dinoflagellate toxins

Iranian South Medical Journal, 2016
Background: Dinoflagellates are the major causative agents of harmful algal blooms. In different studies, it has been shown that many dinoflagellate species produce various natural toxins.
Akram Najafi, Iraj Nabipour
doaj  

Exosomal miR‐4644 Targets SPRY3 to Promote Proliferation and Invasion of Pancreatic Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Tumor‐derived exosomes (TDEs) can carry diverse genetic material that modulates pancreatic cancer (PC) proliferation and invasion. Despite this, the involvement of microRNAs (miRNAs) in TDE‐mediated tumor progression in PC remains inadequately explored. Methods Ultracentrifugation was used to isolate exosomes derived from AsPC‐1 and
Xiangyu Chu, Dongqi Li, Fusheng Zhang, Yongsu Ma, Yongqi Deng, Chen Wang, Xiaodong Tian, Yanlian Yang, Yinmo Yang   +8 more
wiley   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Single‐Cell and Spatial Transcriptomics Uncover Immune Dynamics and Cellular Heterogeneity in Benign Prostatic Hyperplasia and Prostate Cancer Transition

MedComm, Volume 7, Issue 6, June 2026.
Leveraging integrated single‐cell and spatial transcriptomics, we delineated the sustained immunosuppressive landscape during prostate disease progression. Based on this, we have developed a precise gene‐based diagnostic classifier and a multimodal prognostic model.
Yuanyuan Luo, Haitao Zhong, Tongrui Shang, Bin Hu, Dongbo Yuan, Xueyuan Jia, Ruichong Lin, Zehua Wang, Yinyi Fang, Guohua Zhu, Jukun Song, Zhangcheng Liu, Bo Yan, Fa Sun, Zhenyu Jia, Yunfang Yu, Luhui Mao, Hai Huang, Jianguo Zhu   +18 more
wiley   +1 more source

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. [PDF]

, 2020
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered ...
Ceciliato, Paulo HO, Dubeaux, Guillaume, Ge, Chennan, Hauser, Felix, Hsu, Po-Kai, Munemasa, Shintaro, Schroeder, Julian I, Takahashi, Yohei, Zhang, Jingbo, Zhang, Li, Zhao, Yunde   +10 more
core  

Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo‐Immunotherapy in Small Cell Lung Cancer

MedComm, Volume 7, Issue 6, June 2026.
In small cell lung cancer, high tumor ICOSLG expression drives a microenvironment enriched with immunosuppressive T cells and M2 macrophages. Conversely, ICOSLG low tumors promote CD8+ T cell infiltration. Clinically, high ICOSLG levels predict poor response to immune checkpoint inhibitors and worse survival, whereas low ICOSLG expression indicates ...
Qiji Guo, Yan Chen, Jijun Sun, Hongyi Zhang, Shuyu Ji, Huansha Yu, Lele Zhang, Haiyang Hu, Peng Zhang, Jing Zhang   +9 more
wiley   +1 more source

The effect of differentiation on the expression of phosphoprotein phosphatase in the human promyelocytic leukaemic cell line HL-60 [PDF]

, 2006
Student Number : 9000554P - PhD thesis - School of Molecular Medicine and Haematology - Faculty of ScienceDynamic cellular activity is fundamental to all life. Virtually all life processes, are modulated by the reversible phosphorylation of proteins,
Bhoola, Rajesh
core  

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 6, June 2026.
To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
wiley   +1 more source