Results 61 to 70 of about 18,289 (229)

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]

, 2006
Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas, Cirelli, Rosemary, Foster, Gayle C., Hastie, Annette T., Hawkins, Gregory A., Peters, Stephen P., Rybinski, Katherine A., Wu, Min, Zangrilli, James G.   +8 more
core   +1 more source

Gramine derivatives targeting Ca2+ channels and Ser/Thr phosphatases: A new dual strategy for the treatment of neurodegenerative diseases [PDF]

, 2016
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Journal of Medicinal Chemistry , copyright © American Chemical Society after peer review.
Alzheimer A., Carmen Nanclares, Chan S. F., Cristóbal de los Ríos, Juan-Alberto Arranz-Tagarro, Laura González-Lafuente, Luis Gandía, Mark R. J., Monique Araujo de Brito, Raquel L. Arribas, Rocío Lajarín-Cuesta, Settimo A. D.   +11 more
core   +3 more sources

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, EarlyView.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

ANIA:ANnotation and Integrated Analysis of the 14-3-3 interactome [PDF]

, 2014
The dimeric 14-3-3 proteins dock onto pairs of phosphorylated Ser and Thr residues on hundreds of proteins, and thereby regulate many events in mammalian cells.
Baskaran, Bastea, Bier, Carol MacKintosh, Cock, Cohen, Dickerson, Dinkel, Dubois, Edgar, Forbes, Fábio Madeira, Gavuthami Murugesan, Gerta Hoxhaj, Graves, Green, Hornbeck, Hu, Huang da, Huminiecki, Ichimura, Johnson, Johnson, Kasahara, Katoh, Konig, Larance, Larkin, Linding, Makino, Manning, Michele Tinti, Molzan, Notredame, Obenauer, Ostlund, Panni, Pearce, Rachel Toth, Robens, Sievers, Silhan, Tinti, Uhart, UniProt Consortium, Waterhouse, Yaffe, Yaffe, Zanivan, Zanivan, Zhang, Zhao   +51 more
core   +3 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The Versatile Molecular Complex Component LC8 Promotes Several Distinct Steps of Flagellar Assembly [PDF]

, 2012
LC8 is present in various molecular complexes. However, its role in these complexes remains unclear. We discovered that although LC8 is a subunit of the radial spoke (RS) complex in Chlamydomonas flagella, it was undetectable in the RS precursor that is ...
Anjali Gupta, Barbar, Bergen, Bloch, Dennis R. Diener, DiBella, Diener, Diener, Dymek, Dymek, Espindola, Fejtova, Gaillard, Hall, Harris, Heuser, Huang, Jaffrey, Jivan, Joel L. Rosenbaum, Johnson, Kamiya, Kindle, King, LeDizet, Liang, Lightcap, Lin, Lo, Lo, Luo, Naisbitt, Navarro-Lérida, Nicastro, Patel-King, Pazour, Pazour, Pfister, Pigino, Pinfen Yang, Piperno, Piperno, Porter, Priyanka Sivadas, Puthalakath, Qin, Rodríguez-Crespo, Rompolas, Sakato, Segal, Stelter, Summers, Tan, Warner, Wei, Williams, Wirschell, Yang, Yang, Yang, Yang, Yang   +61 more
core   +2 more sources

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase

The EMBO Journal
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle ...
Hongbin Yang, Paul Smith, Yingying Ma, Emily Southworth, Varun Gopala Krishna, Beatrice Salerno, Joseph Rowland, Alexander E P Loftus, Domenico Grieco, Iolanda Vendrell, Roman Fischer, Benedikt M Kessler, Vincenzo D’Angiolella   +12 more
doaj   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Quantitative in vivo phosphoproteomics reveals reversible signaling processes during nitrogen starvation and recovery in the biofuel model organism Chlamydomonas reinhardtii

Biotechnology for Biofuels, 2017
Background Nitrogen deprivation and replenishment induces massive changes at the physiological and molecular level in the green alga Chlamydomonas reinhardtii, including reversible starch and lipid accumulation.
Valentin Roustan, Shiva Bakhtiari, Pierre-Jean Roustan, Wolfram Weckwerth   +3 more
doaj   +1 more source