Results 291 to 300 of about 73,329 (379)

Self‐Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
We report the development and application of a mouse ovarian somatic organoid model to elucidate a fundamental new understanding of the cell biology of the aging ovarian microenvironment. ABSTRACT Ovarian somatic cells are essential for reproductive function, but no existing ex vivo models recapitulate the cellular heterogeneity or interactions within ...
Shweta S. Dipali   +10 more
wiley   +1 more source

DDR1 Regulates Femoral Arterial Calcification in Lower‐Extremity Artery Disease Through NF‐Kappa B Activation

open access: yesActa Physiologica, Volume 242, Issue 1, January 2026.
ABSTRACT Aim Lower‐extremity arterial disease (LEAD) is a manifestation of atherosclerotic cardiovascular disease, affecting 230 million people worldwide with increasing prevalence. Medial arterial calcification (MAC) is common in LEAD patients and contributes to disease‐related mortality.
Manovriti Thakur   +13 more
wiley   +1 more source

Synthetic trap‐peptides identify a TOM complex phosphatase – PP2A dephosphorylates Tom6

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 271-294, January 2026.
Synthetic trap‐peptides facilitate the identification of complete holoenzymes that bind to the target sequence remarkably close to the phosphorylation site. PP4 bound to, but did not dephosphorylate, the peptide substrate taken from yeast Tom6 pSer16, showing that proximity alone does not induce phosphatase activity.
Laura Scheinost   +7 more
wiley   +1 more source

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