Results 241 to 250 of about 27,576 (286)
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Analytica Chimica Acta, 2021
Phosphorylation is one of the quickest post-translational modifications that controls downstream signaling pathways regulating processes like cell proliferation, survival, and differentiation. Nowadays, mass spectrometry-based phosphoproteomics is a well-
J. Urban
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Phosphorylation is one of the quickest post-translational modifications that controls downstream signaling pathways regulating processes like cell proliferation, survival, and differentiation. Nowadays, mass spectrometry-based phosphoproteomics is a well-
J. Urban
semanticscholar +1 more source
Computational systems approach towards phosphoproteomics and their downstream regulation
Proteomics, 2022Protein phosphorylation plays an essential role in modulating cell signalling and its downstream transcriptional and translational regulations. Until recently, protein phosphorylation has been studied mostly using low‐throughput biochemical assays.
Di Xiao, Carissa Chen, Pengyi Yang
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2011
The identification of phosphorylation on proteins has become practicable for many laboratories in recent years, largely due to improvements in mass spectrometry (MS) and the development of methods to selectively enrich for phosphorylated peptides and proteins.
Alexandra M E, Jones, Thomas S, Nühse
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The identification of phosphorylation on proteins has become practicable for many laboratories in recent years, largely due to improvements in mass spectrometry (MS) and the development of methods to selectively enrich for phosphorylated peptides and proteins.
Alexandra M E, Jones, Thomas S, Nühse
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Phosphoproteome of Cryptococcus neoformans
Journal of Proteomics, 2014Cryptococcus neoformans is an encapsulated pathogenic yeast, which causes life threatening meningitis in immunocompromised individuals. C. neoformans var. grubii is the most prevalent and virulent form among the two varieties of C. neoformans - C. neoformans var. grubii and C. neoformans var. neoformans. The virulence of C.
Lakshmi Dhevi N, Selvan +10 more
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Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors.
ACS Chemical Biology, 2021Due to its important roles in oncogenic signaling, AKT has been subjected to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials.
S. Wiechmann +10 more
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Analytical Chemistry, 2020
The heterogeneous populations of exosomes with distinct nano-size have impeded our understanding of their corresponding function as intercellular communication agents. Profiling signaling proteins packaged in each size-dependent subtype can disclose this
Haoyang Zheng +5 more
semanticscholar +1 more source
The heterogeneous populations of exosomes with distinct nano-size have impeded our understanding of their corresponding function as intercellular communication agents. Profiling signaling proteins packaged in each size-dependent subtype can disclose this
Haoyang Zheng +5 more
semanticscholar +1 more source
Illuminating the dark phosphoproteome
Science Signaling, 2019Identifying the targets of “dark” kinases will provide new biological and disease insights.
Elise J. Needham +4 more
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Phosphoproteomics takes it easy
Nature Biotechnology, 2015The EasyPhos pipeline simplifies analysis of phosphorylation-dependent signaling networks at high temporal resolution.
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2015
Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
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Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
openaire +2 more sources
2020
In contrast to the canonical phosphoproteomes (P-Ser, P-Thr, P-Tyr), the noncanonial phosphoproteomes include phosphorylated side chains not typically acid-stable and thus often missed in standard phosphopeptide mass spectrometry protocols. In this regard the N-phosphohistidinyl residues, the beta aspartyl-phosphate residues, and the S-phosphocysteinyl
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In contrast to the canonical phosphoproteomes (P-Ser, P-Thr, P-Tyr), the noncanonial phosphoproteomes include phosphorylated side chains not typically acid-stable and thus often missed in standard phosphopeptide mass spectrometry protocols. In this regard the N-phosphohistidinyl residues, the beta aspartyl-phosphate residues, and the S-phosphocysteinyl
openaire +1 more source