Results 1 to 10 of about 26,651 (230)

De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans [PDF]

Communications Biology
To secure an adequate nicotinamide adenine dinucleotide (NAD+) supply for survival, organisms typically rely on two complementary mechanisms: the de novo synthesis pathway and the salvage pathway.
Shihao Zhu, Runshuai Zhang, Luxia Yao, Zhirong Lin, Yanjie Li, Siyuan Li, Lianfeng Wu   +6 more
doaj   +2 more sources

Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Obstructive sleep apnoea (OSA) occurs frequently among individuals with obesity, which is attributed to upper airway muscle dysfunction. Muscle function is regulated by the dynamic balance of the nicotinamide adenine dinucleotide (NAD+) and ...
Liu Zhang, Ya Ru Yan, Shi Qi Li, Ying Ni Lin, Yi Wang, Yu Qing Wang, Ning Li, Fang Ying Lu, Xian Wen Sun, Li Yue Zhang, Jian Ping Zhou, Yong Jie Ding, Qing Yun Li   +12 more
doaj   +2 more sources

Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 [PDF]

Microb Biotechnol
In this study, we examined the highly conserved upp gene in bifidobacteria, which encodes uracil phosphoribosyltransferase and plays a role in the pyrimidine salvage pathway. Specifically, we explore its evolutionary trajectory in bifidobacteria, shedding light on its role in microbial competition in the human gut.
Longhi G, Petraro S, Milani C, Tarracchini C, Argentini C, Vergna L, Lugli G, Mancabelli L, Lee C, Turroni F, van Sinderen D, Ventura M.   +11 more
europepmc   +2 more sources

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma [PDF]

Blood Advances
: Elevated levels of the NAD+-generating enzyme nicotinamide phosphoribosyltransferase (NAMPT) are a common feature across numerous cancer types.
Debora Soncini, Pamela Becherini, Francesco Ladisa, Silvia Ravera, Adithya Chedere, Elisa Gelli, Giulia Giorgetti, Claudia Martinuzzi, Francesco Piacente, Luca Mastracci, Claudia Veneziano, Gianluca Santamaria, Fiammetta Monacelli, Moustafa S. Ghanem, Antonia Cagnetta, Fabio Guolo, Matteo Garibotto, Sara Aquino, Mario Passalaqua, Santina Bruzzone, Axel Bellotti, Michel A. Duchosal, Aimable Nahimana, Emanuele Angelucci, Chandra Nagasuma, Alessio Nencioni, Roberto Massimo Lemoli, Michele Cea   +27 more
doaj   +2 more sources

Human Adenine Phosphoribosyltransferase

Journal of Biological Chemistry, 1973
Cornelius B. Thomas, William J. Arnold, William N. Kelley   +2 more
openalex   +3 more sources

Adenine Phosphoribosyltransferase Deficiency [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Complete adenine phosphoribosyltransferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. The low solubility of DHA results in precipitation of this compound and the formation of urinary crystals and stones.
Guillaume Bollée, Michel Daudon, Albert Bensman, Irène Ceballos-Picot, Jérôme Harambat, Bertrand Knebelmann   +5 more
openaire   +3 more sources

Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates

Frontiers in Bioengineering and Biotechnology, 2020
In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT ...
Javier Acosta, Jon Del Arco, Maria Luisa Del Pozo, Beliña Herrera-Tapias, Vicente Javier Clemente-Suárez, Vicente Javier Clemente-Suárez, José Berenguer, Aurelio Hidalgo, Jesús Fernández-Lucas, Jesús Fernández-Lucas   +9 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Late diagnosis of Lesch–Nyhan disease complicated with end-stage renal disease and tophi burst: a case report

Renal Failure, 2020
Background Lesch–Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.
Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana   +6 more
doaj   +1 more source

Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2000
Guanine phosphoribosyltransferase from Giardia lamblia, a key enzyme in the purine salvage pathway, is a potential target for anti-giardiasis chemotherapy. Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. L., and Almo, S. C.
Narsimha R. Munagala, Ching C. Wang, Anne E. Sarver   +2 more
openaire   +3 more sources