Results 91 to 100 of about 37,163 (226)

Epiafzelechin, a Flavanol, Regulates Lipid Homeostasis Through Modulation of HMGCR, PCSK9, and PPAR‐α: Mechanistic Insights and Therapeutic Implications

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Saud O. Alshammari, Nazifa Shahzad, Muhammad Nasir Hayat Malik, Qamar A. Alshammari, Abdulkarim Alshammari, Bassam S. M. Al Kazman, Muhammad Atif, Gideon F. B. Solre, Vivek Pandey   +8 more
wiley   +1 more source

Dihydroxyadenine crystal-induced nephropathy presenting with rapidly progressive renal failure

Kidney Research and Clinical Practice, 2018
Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis.
Ritu Verma, Manickam Niraimathi, Pallavi Prasad, Vinita Agrawal   +3 more
doaj   +1 more source

Prioritization of Deleterious Variations in the Human Hypoxanthine-Guanine Phosphoribosyltransferase Gene

Medical Laboratory Journal, 2018
Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders.
Semira Kheiri, Mahdieh Safarzad, Mohammad Shariati, Hoda Sohrabi   +3 more
doaj  

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice [PDF]

, 2013
Rafaela da Silva, Rafaela da Silva, Sabine Steffens, Mathias Fabre, Inga Bauer, Irene Caffa, Mirko Magnone, Giovanna Sociali, Alessandra Quercioli, Graziano Pelli, Sébastien Lenglet, Katia Galan, Fabienne Burger, Simonetta Calvo, Maria Bertolotto, Santina Bruzzone, Alberto Ballestrero, Franco Patrone, Franco Dallegri, Robson A.S. Santos, Nikolaos Stergiopulos, François Mach, Nicolas Vuilleumier, Fabrizio Montecucco, Alessio Nencioni   +24 more
openalex   +1 more source

Changes of Nicotinamide Phosphoribosyltransferase Expressions in Thyroid Glands of Patients with Different Thyroid Pathologies [PDF]

, 2018
Nadia Sawicka‐Gutaj, Mirosław Andrusiewicz, Agata Czarnywojtek, Joanna Waligórska‐Stachura, Maciej Biczysko, J Skrobisz, Jerzy Sowiński, Marek Ruchała   +7 more
openalex   +1 more source

Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Cell Death Discovery
Nicotinamide adenine dinucleotide (NAD⁺) is a critical coenzyme involved in cellular metabolism, energy balance, and various physiological processes.
Weijia Zhang, Haoyu Ren, Wangwang Chen, Bo Hu, Chao Feng, Peishan Li, Yufang Shi, Jiankai Fang   +7 more
doaj   +1 more source

Human hypoxanthine-guanine phosphoribosyltransferase.

, 1983
James M. Wilson, Ryōji Kobayashi, Irving H. Fox, William N. Kelley   +3 more
openalex   +1 more source

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation

, 2019
Tomáš Klejch, Dianne T. Keough, Marina Chavchich, Jye Travis, Jan Skácel, Radek Pohl, Zlatko Janeba, Michael D. Edstein, Vicky M. Avery, Luke W. Guddat, Dana Hocková   +10 more
openalex   +2 more sources

Yeast GMP Kinase Mutants Constitutively Express AMP Biosynthesis Genes by Phenocopying a Hypoxanthine-Guanine Phosphoribosyltransferase Defect [PDF]

, 2000
Karine Lecoq, Manfred Konrad, Bertrand Daignan‐Fornier   +2 more
openalex   +1 more source

Localization and Targeting of the Leishmania donovaniHypoxanthine-Guanine Phosphoribosyltransferase to the Glycosome

, 1998
Sarah Shih, Ho‐Yon Hwang, Darrick Carter, Paula E. Stenberg, Buddy Ullman   +4 more
openalex   +1 more source