Results 91 to 100 of about 26,651 (230)

Adenine phosphoribosyltransferase deficiency and 2, 8-dihydroxyadenine renal stones: A preventable cause of pediatric renal stones and kidney disease

Saudi Journal of Kidney Diseases and Transplantation, 2019
Adenine phosphoribosyltransferase deficiency is an inherited condition presenting from infancy to late adulthood. The common features are recurrent kidney and urinary tract stones and obstructive symptoms. The stones are characteristically radiolucent. 2,
Mital Dipakkkumar Parikh, Abhijit Konnur, Sishir Gang   +2 more
doaj   +1 more source

Differences in mRNA Expression of Selected Cytochrome P450, Transporters and Nuclear Receptors Among Various Rat Models of Metabolic Syndrome

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
Metabolic syndrome (MetS) is a combination of several factors, which lead to a higher risk of cardiovascular and other diseases. To study MetS, its mechanisms and means to alleviate complications associated with it, there is a demand for suitable animal models and their strains.
Jan Soukop, Zuzana Rácová, Ludmila Kazdová, Iveta Zapletalová, Martin Poruba, Hana Malínská, Martina Hüttl, Irena Marková, Kristýna Nováková, Rostislav Večeřa   +9 more
wiley   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Studies on the nature of the regulation by purine nucleotides of adenine phosphoribosyltransferase and of hypoxanthine phosphoribosyltransferase from Ehrlich ascites-tumour cells [PDF]

, 1967
AW Murray
openalex   +1 more source

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

British Journal of Pharmacology, Volume 182, Issue 16, Page 3903-3922, August 2025.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács, Tamás Kovács, András Lánczky, Ágnes Paál, Zsombor I. Hegedűs, Nabil V. Sayour, Lilla Szabó, Andrea Kovács, Giampaolo Bianchini, Péter Ferdinandy, Alberto Ocana, Zoltán V. Varga, János Tibor Fekete, Balázs Győrffy   +13 more
wiley   +1 more source

Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man [PDF]

, 1968
William N. Kelley, Robert I. Levy, Frederick M. Rosenbloom, Jane Henderson, J. Edwin Seegmiller   +4 more
openalex   +1 more source

Nicotinamide Phosphoribosyltransferase as a Target in Inflammation- Related Disorders

Current Topics in Medicinal Chemistry, 2013
NAD⁺ biosynthesis through nicotinamide phosphoribosyltransferase (NAMPT) holds potential as a target for the treatment of inflammatory disorders due to NAD(+)'s role in immune cell signaling and metabolism. In addition to its activity as an enzyme, NAMPT is also secreted in the extracellular space where it acts as a pro-inflammatory and proangiogenic ...
MONTECUCCO, FABRIZIO, CEA, MICHELE, CAGNETTA, ANTONIA, DAMONTE, PATRIZIA, Nahimana A, BALLESTRERO, ALBERTO, Del Rio A, BRUZZONE, SANTINA, NENCIONI, ALESSIO   +8 more
openaire   +5 more sources

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Construction of Deletion-knockout Mutant Fowlpox Virus (FWPV)

Bio-Protocol, 2014
The construction of deletion-knockout poxviruses is a useful approach to determining the function of specific virus genes. This protocol is an adaptation of the transient dominant knockout selection protocol published by Falkner and Moss (1990) for use ...
Stephen Laidlaw, Michael Skinner
doaj   +1 more source

Human erythrocyte AMP: Pyrophosphate phosphoribosyltransferase (EC 2.4.2.7) [PDF]

, 1968
B.M. Dean, R. W. E. Watts, Wendy J. Westwick   +2 more
openalex   +1 more source