Results 101 to 110 of about 55,635 (283)
Purine Phosphoribosyltransferases [PDF]
Journal of Biological Chemistry, 2000 S P, Craig, A E, Eakin
openaire +2 more sources
Aging Cell, Volume 25, Issue 5, May 2026.We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima +19 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi +14 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 喹啉酸磷酸核糖转移酶(quinolinate phosphoribosyltransferase,QPRT)是色氨酸代谢过程中的关键酶,近年来,研究发现QPRT不仅参与诸多神经系统疾病的发病机制,还与感染性疾病、肿瘤的发生有关,本文就此进行综述。
张楠楠, 赵瑞鹏, 施建华
doaj
Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]
, 2012 Peer reviewedPublisher ...
Agouni, Abdelali +3 more
core +3 more sources
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source
The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: MiR-21 and promoter methylation [PDF]
, 2016 Background: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development.
Azadeh, H. +3 more
core +1 more source
Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]
, 2018 The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R +4 more
core +1 more source
Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi +14 more
wiley +1 more source