Results 121 to 130 of about 55,635 (283)

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

, 2017
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer.
Agirre, Xabier, Apaolaza, Iñigo, Atauri, Pedro de, Carracedo, Arkaitz, Cascante i Serratosa, Marta, Cendoya, Xabier, Garate, Leire, Miranda, Estíbaliz, Ochoa, María Carmen, Pey, Jon, Planes, Francisco J., Prosper, Felipe, Rubio, Angel, San José-Eneriz, Edurne   +13 more
core   +3 more sources

Prioritization of Deleterious Variations in the Human Hypoxanthine-Guanine Phosphoribosyltransferase Gene

Medical Laboratory Journal, 2018
Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders.
Semira Kheiri, Mahdieh Safarzad, Mohammad Shariati, Hoda Sohrabi   +3 more
doaj  

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis [PDF]

, 2023
Xu Sun, Lide Su, Te Bu, Yang Zhang
openalex   +1 more source

Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Cell Death Discovery
Nicotinamide adenine dinucleotide (NAD⁺) is a critical coenzyme involved in cellular metabolism, energy balance, and various physiological processes.
Weijia Zhang, Haoyu Ren, Wangwang Chen, Bo Hu, Chao Feng, Peishan Li, Yufang Shi, Jiankai Fang   +7 more
doaj   +1 more source

Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy [PDF]

Background:Dogs with dystrophin-deficient muscular dystrophy are valuable models of the equivalent human disease, Duchenne Muscular Dystrophy (DMD): unlike the mdx mouse, these animals present a disease severity and progression that closely matches that ...
Aartsma-Rus, Ali, Andersen, Bages, Bello, Bish, Breitbart, Brinkmeyer-Langford, Burton, Bustin, Bustin, Camerino, Cohn, Cotten, Craig, Crist, Duan, Falzarano, Feder, Fjeldbo, Flanigan, Galindo, Gong, Hildyard, Kallestad, Kornegay, Kornegay, Li, Liu, Mah, McGreevy, Nghiem, Pegoraro, Pfaffl, Piva, Reinig, Rho, Robinson-Hamm, Robriquet, Schmittgen, Solano, Spassov, Swaggart, Thellin, Vieira, Vieira Natassia, Walmsley, Webster, Wuebbles, Yu, Zammit   +50 more
core   +1 more source

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation. [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP ...
Chen, Jingwen, Cheng, Qinqin, Dai, Zhefu, Evdokimov, Nikolai M, Lam, Albert T, Louie, Stan G, Lu, Yanran, Pei, Hua, Zhang, Xiao-Nan, Zhang, Yong   +9 more
core   +1 more source

Decision letter: Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

, 2017

openalex   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy [PDF]

, 2018
Changgui Shi, Huiqiao Wu, Di Du, Hee‐Jeong Im, Ying Zhang, Bo Hu, Huajiang Chen, Xinwei Wang, Yang Liu, Peng Cao, Ye Tian, Xiaolong Shen, Rui Gao, André J. van Wijnen, Xiaojian Ye, Wen Yuan   +15 more
openalex   +1 more source

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity [PDF]

, 2011
BACKGROUND AND AIMS: Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation.
Catalan, V. (Victoria), Frühbeck, G. (Gema), Gomez-Ambrosi, J. (Javier), Ramirez, B. (Beatriz), Rodriguez, A. (Amaia), Rotellar, F. (Fernando), Salvador, J. (Javier), Silva, C. (Camilo), Álvarez-Cienfuegos, J. (Javier)   +8 more
core  

Data from Dual Targeting of Tumor Angiogenesis and Chemotherapy by Endostatin–Cytosine Deaminase–Uracil Phosphoribosyltransferase

, 2023
Chun‐Te Chen, Hirohito Yamaguchi, Hong-Jen Lee, Yi Du, Heng‐Huan Lee, Weiya Xia, Wen-Hsuan Yu, Jennifer L. Hsu, Chia‐Jui Yen, Hui‐Lung Sun, Yan Wang, Edward T.H. Yeh, Gabriel N. Hortobágyi, Mien‐Chie Hung   +13 more
openalex   +1 more source